Table 3.
Profile of TP 53 mutations in 157 gliomas according to the histological diagnosis
| DA | OL | OA | AA | AO | AOA | pGBM | sGBM | Total | |
|---|---|---|---|---|---|---|---|---|---|
| Mutation | |||||||||
| Present | 16 | 0 | 1 | 17 | 0 | 4 | 24 | 4 | 66 |
| Absent | 12 | 2 | 5 | 12 | 5 | 15 | 38 | 2 | 91 |
| Total | 28 | 2 | 6 | 29 | 5 | 19 | 62 | 6 | 157 |
| Frequency (%) | 57.1 | 0.0 | 16.7 | 58.6 | 0.0 | 21.1 | 38.7 | 66.7 | 42.0 |
| Location | |||||||||
| Exon 4 | 1 | 0 | 0 | 2 | 0 | 1 | 2 | 0 | 6 |
| Exon 5 | 3 | 0 | 0 | 3 | 0 | 1 | 9 | 2 | 18 |
| Exon 6 | 3 | 0 | 0 | 5 | 0 | 1 | 2 | 1 | 12 |
| Exon 7 | 3 | 0 | 0 | 6 | 0 | 0 | 5 | 0 | 14 |
| Exon 8 | 5 | 0 | 1 | 3 | 0 | 1 | 5 | 2 | 17 |
| Exon 9 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| Exon 10 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 4 |
| Mutation type | |||||||||
| Missense | 14 | 0 | 1 | 15 | 0 | 3 | 22 | 5 | 60 |
| Nonsense | 1 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 5 |
| Frameshift | 1 | 0 | 0 | 2 | 0 | 1 | 3 | 0 | 7 |
Abbreviations: AA = anaplastic astrocytoma grade III; AO = anaplastic oligodendroglioma grade III; AOA = anaplastic oligoastrocytoma grade III; DA = diffuse astrocytoma grade II; OA = oligoastrocytoma grade II; OL = oligodendroglioma grade II; pGBM = primary glioblastoma; sGBM = secondary glioblastoma defined by clinical history.