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. 2014 Dec 17;25(1):63–78. doi: 10.1111/bpa.12218

Figure 5.

figure

Leptomeningeal arteries from wild‐type and APOE ε4 mice following intracerebral injection of fluorescent Aβ (green). Within 5 minutes of the injection, Aβ was observed along basement membranes, colocalizing (pink) with collagen IV (blue) in young, 3‐month‐old wild‐type mice in (A). Aggregation of Aβ is seen as early as 3 months in the APOE4 mice (arrow in B). Aβ continues to drain along basement membranes of aged wild‐type mice (C), but appears as large deposits in 16 months in the APOE ε4 mice (D, arrows). Scale bars = 10 μm in A; 25 μm in B, C and D. Reproduced from reference 50.