Table 1.
EtOH‐regulated astrocyte‐enriched genes. Abbreviations: MPE = male WSP ethanol; MPA = male WSP control; MRE = male WSR ethanol; MRA = male WSR control; FPE = female WSP ethanol; FPA = female WSP control; FRE = female WSR ethanol; FRA = female WSR control
| GeneID | ACC | UGCluster | Name | Symbol | 0 h MPE‐MPA | 0 h MRE‐MRA | 0 h FPE‐FPA | 0 h FRE‐FRA | 8 h MPE‐MPA | 8 h MRE‐MRA | 8 h FPE‐FPA | 8 h FRE‐FRA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 66278 | AI426191 | Mm.27900 | RIKEN cDNA 1810013D10 gene | 1810013D10Rik | 0.148 | −0.132 | −0.805 | −0.83 | −0.545 | 0.188 | −0.02 | −0.097 |
| 75572 | AI327338 | Mm.390319 | Acylphosphatase 2, muscle type | Acyp2 | −0.176 | −0.177 | −1.149 | −0.591 | −0.026 | −0.328 | −0.249 | 0.02 |
| 27360 | AI324178 | Mm.426080 | Adducin 3 (gamma) | Add3 | 0.114 | 0.338 | −0.323 | −0.252 | 0.168 | −0.547 | 0.19 | 0.166 |
| 27360 | AI449373 | Mm.426080 | Adducin 3 (gamma) | Add3 | 0.114 | 0.338 | −0.323 | −0.252 | 0.168 | −0.547 | 0.19 | 0.166 |
| 52231 | AI465332 | Mm.259326 | Ankyrin repeat and zinc finger domain containing 1 | Ankzf1 | −0.268 | 0.04 | −1.468 | −0.406 | −0.375 | −0.683 | 0.676 | 0.519 |
| 52231 | AI425962 | Mm.259326 | Ankyrin repeat and zinc finger domain containing 1 | Ankzf1 | −0.268 | 0.04 | −1.468 | −0.406 | −0.375 | −0.683 | 0.676 | 0.519 |
| 11886 | AI413346 | Mm.22547 | N‐acylsphingosine amidohydrolase 1 | Asah1 | 0.096 | 0.452 | −0.317 | −1.029 | 0.064 | 0.217 | 0.081 | −0.231 |
| 65973 | AI451660 | Mm.222206 | Aspartate‐beta‐hydroxylase | Asph | 0.248 | −0.344 | −0.699 | 0.265 | 0.3 | −0.28 | 0.62 | 0.861 |
| 12419 | AI893653 | Mm.262059 | Chromobox homolog 5 (Drosophila HP1a) | Cbx5 | 0.039 | −0.016 | −0.677 | −0.293 | −0.405 | 0.212 | −0.025 | −0.059 |
| 12419 | AI450379 | Mm.262059 | Chromobox homolog 5 (Drosophila HP1a) | Cbx5 | 0.039 | −0.016 | −0.677 | −0.293 | −0.405 | 0.212 | −0.025 | −0.059 |
| 12212 | AI452330 | Mm.42223 | Cysteine‐rich hydrophobic domain 1 | Chic1 | −0.109 | −0.125 | 0.633 | −0.148 | −0.283 | 0.257 | −0.014 | 0.164 |
| 70568 | AI451962 | Mm.38390 | Copine III | Cpne3 | −0.151 | −0.052 | 0.303 | 0.826 | 0.506 | 0.273 | 0.254 | −0.011 |
| 13198 | AI323295 | Mm.110220 | DNA‐damage inducible transcript 3 | Ddit3 | −0.088 | −0.103 | −0.445 | 0.469 | −0.014 | 0.102 | 0.343 | −0.219 |
| 68187 | AI465387 | Mm.87130 | Family with sequence similarity 135, member A | Fam135a | −0.361 | −0.079 | 1.259 | −0.879 | 0.094 | 0.122 | 0.122 | 0.31 |
| 14221 | AI465262 | Mm.29730 | Four jointed box 1 (Drosophila) | Fjx1 | 0.039 | −0.037 | −0.383 | 0.526 | −0.009 | −0.03 | 0.079 | −0.263 |
| 233899 | AI415639 | Mm.25220 | Predicted gene 166 | Gm166 | −0.193 | −0.051 | 0.018 | 1.146 | 0.135 | 0.083 | 0.045 | 0.25 |
| 215798 | AI449247 | Mm.440142 | G‐protein coupled receptor 126 | Gpr126 | 0.053 | −0.141 | 1.529 | 0.223 | 0.267 | −0.233 | 0.516 | −0.114 |
| 53379 | AI449004 | Mm.155896 | Heterogenous nuclear ribonucleoprotein A2/B1 | Hnrnpa2b1 | −0.268 | 0.392 | −0.491 | −0.25 | 0.356 | 0.09 | 0.237 | 0.001 |
| 16848 | AI451068 | Mm.12834 | LFNG O‐fucosylpeptide 3‐beta‐N‐acetylglucosaminyltransferase | Lfng | −0.354 | 0.13 | −0.23 | 1.416 | −0.34 | −0.115 | 0.06 | 0.296 |
| 16905 | AI464505 | Mm.243014 | Lamin A | Lmna | −0.156 | 0.034 | −0.39 | 0.029 | −0.017 | −0.323 | 0.33 | 0.257 |
| 11426 | AI449659 | Mm.402299 | Microtubule‐actin cross‐linking factor 1 | Macf1 | −0.419 | 0.428 | −0.474 | 0.733 | 0.237 | −0.176 | 0.222 | −0.088 |
| 69900 | AI415185 | Mm.348004 | Major facilitator superfamily domain containing 11 | Mfsd11 | 0.14 | −0.429 | −0.233 | −0.469 | −0.19 | 0.197 | 0.066 | −0.306 |
| 171580 | AI447388 | Mm.290431 | Microtubule associated monoxygenase, calponin and LIM domain containing 1 | Mical1 | −0.224 | 0.066 | 0.074 | −0.073 | −0.016 | 0.049 | −0.317 | −0.384 |
| 382793 | AI428081 | Mm.296770 | Metaxin 3 | Mtx3 | −0.053 | 0.478 | −0.011 | 0.646 | −0.454 | −0.13 | 0.326 | −0.389 |
| 210622 | AI414397 | Mm.28649 | Peptidase domain containing associated with muscle regeneration 1 | Pamr1 | −0.028 | −0.319 | −0.069 | −0.062 | −0.523 | 0.011 | −0.1 | 0.125 |
| 235587 | AI451081 | Mm.273659 | Poly (ADP‐ribose) polymerase family, member 3 | Parp3 | 0.389 | −0.144 | 0.181 | 0.517 | −0.128 | 0.114 | 0.767 | −0.359 |
| 18578 | AI452258 | Mm.20181 | Phosphodiesterase 4B, cAMP specific | Pde4b | −0.249 | −0.402 | 0.603 | 0.836 | 0.106 | 0.294 | −0.017 | 0.111 |
| 18933 | AI447573 | Mm.288642 | Paired related homeobox 1 | Prrx1 | 0.091 | −0.044 | −0.157 | 0.196 | 0.075 | 0.143 | 0.034 | −0.177 |
| 19659 | AI893623 | Mm.279741 | Retinol binding protein 1, cellular | Rbp1 | 0.306 | 0.179 | −0.14 | −0.426 | −0.184 | −0.265 | 0.493 | −0.192 |
| 58887 | AI425994 | Mm.219183 | Replication initiator 1 | Repin1 | 0.109 | −0.041 | −0.011 | −0.103 | 0.087 | −0.384 | 0.218 | 0.476 |
| 244058 | AI429605 | Mm.333943 | RGM domain family, member A | Rgma | −0.185 | −0.451 | 0.191 | −0.201 | −0.376 | 0.172 | −0.332 | −0.058 |
| 11853 | AI324259 | Mm.262 | Ras homolog gene family, member C | Rhoc | 0.024 | 0.159 | 0.251 | 1.453 | −0.035 | 0.087 | 0.264 | −0.202 |
| 20516 | AI415416 | Mm.323901 | Solute carrier family 20, member 2 | Slc20a2 | 0.448 | −0.393 | 0.133 | 0.644 | 0.312 | 0.074 | −0.368 | 0.478 |
| 66500 | AI451495 | Mm.34550 | Solute carrier family 30 (zinc transporter), member 7 | Slc30a7 | 0.104 | −0.135 | −0.454 | −0.115 | 0.022 | −0.303 | 0.553 | 0.426 |
| 20751 | AI894147 | Mm.28393 | Sepiapterin reductase | Spr | 0.4 | 0.032 | −0.86 | −0.581 | 0.207 | −0.543 | 1.028 | 0.38 |
| 107513 | AI452176 | Mm.426670 | Signal sequence receptor, alpha | Ssr1 | −0.178 | −0.12 | −0.899 | −0.129 | 0.041 | 0.008 | 0.342 | 0.506 |
| 272589 | AI451204 | Mm.34483 | Tubulin folding cofactor E‐like | Tbcel | −0.337 | 0.398 | −0.066 | −0.182 | 0.173 | −0.415 | −0.085 | −0.073 |
| 76355 | AI325957 | Mm.251537 | TDP‐glucose 4,6‐dehydratase | Tgds | 0.311 | 0.103 | −0.578 | 0.146 | 0.357 | −0.306 | −0.028 | 0.213 |
| 68059 | AI448035 | Mm.275191 | Transmembrane 9 superfamily member 2 | Tm9sf2 | 0.052 | 0.012 | −0.793 | −1.04 | −0.342 | −0.256 | 0.422 | 0.024 |
| 30935 | AI429495 | Mm.206737 | Torsin family 3, member A | Tor3a | −0.087 | −0.003 | −0.844 | 0.215 | −0.353 | 0.275 | 0.138 | 0.104 |
| 66637 | AI450184 | Mm.379120 | TRNA splicing endonuclease 15 homolog (Saccharomyces cerevisiae) | Tsen15 | −0.311 | −0.087 | −0.443 | −0.602 | −0.459 | −0.241 | 0.065 | 0.694 |
| 67120 | AI426949 | Mm.275710 | Tetratricopeptide repeat domain 14 | Ttc14 | −0.021 | 0.01 | −0.87 | −0.08 | −0.352 | −0.702 | 0.518 | 0.317 |
| 72114 | AI428386 | Mm.3774 | Zinc finger, BED domain containing 3 | Zbed3 | −0.072 | 0.175 | −1.058 | 0.225 | −0.844 | −0.294 | 0.443 | −0.361 |
| 233410 | AI447270 | Mm.29525 | Zinc finger protein 592 | Zfp592 | −0.46 | 0.091 | −0.493 | −1.945 | −0.094 | 0.302 | −0.256 | −0.007 |
Fold change in gene expression, with significantly regulated genes highlighted in bold at 0 h (immediately after chronic EtOH) and 8 h (peak withdrawal).