Table 2.
Transmission of sCJD MM1+2C, MM1 or MM2C to PrP‐humanized knock‐in mice
| Inoculum (ID) | Mouse line (human PRNP genotypes at codons 129 and 219) | ||||
|---|---|---|---|---|---|
| Ki‐Hu129M/M (M/M, E/E) | Ki‐Hu129M/V (M/V, E/E) | Ki‐Hu129V/V (V/V, E/E) | Ki‐Hu219K/K (M/M, K/K) | Ki‐ChM | |
| MM1+2C (case #1) | 615 ± 8 (6/6)a | ND | 717 ± 44 (6/6) | 647 ± 49 (5/5) | 162 ± 13 (6/6) |
| MM1+2C (case #2) | 580 ± 8 (5/5) | 595 ± 6 (4/4) | 588 ± 11 (4/4) | 594 ± 10 (5/5) | 160 ± 9 (4/4) |
| MM1 (H3)b | 467 ± 24 (8/8) | 490 ± 26 (5/5) | 774 ± 32 (6/6) | 573 ± 52 (5/5) | 142 ± 3 (5/5) |
| MM1 (NR) | 531 ± 47 (5/5) | 508 ± 55 (6/6) | 588 ± 3 (5/5) | 527 ± 31 (6/6) | 154 ± 5 (6/6) |
| MM2Cc | — (0/7) | — (0/7) | — (0/7) | — (0/8) | — (0/6) |
a
Mean incubation periods (days ± SEM) and attack rates (number of mice positive for PrP accumulation in immunohistochemical analysis/number of inoculated mice).
c
None of the sCJD MM2C prion‐inoculated mice had developed disease by the end of their life span. Transmission data of Ki‐Hu129M/M, Ki‐Hu129M/V and Ki‐Hu129V/V have been reported previously 18.
Abbreviation: ND = not done.