Figure 4.

Immunoexpression patterns of aquaporin 4 ( AQP 4) and glutamate transporter 1 protein ( GLT ‐1), low power view. AQP4 shows a dense‐diffuse expression pattern in all cortical layers with sparing of the white matter in the cortices of aged control patients (A), whereas the expression is restricted mostly to the upper and lower cortical layers together with a diffuse pattern in the white matter, for perilesional cortices (B). GLT‐1 exhibits the same dense‐diffuse expression, but restricted even more to the upper and lower cortical layers, and with no obvious difference between age controls (data not shown) and perilesional cortices (C). Near an old cavitation site, AQP4 is present in the inner wall of the glial scar, the immunostaining variably diminishing with the increasing distance from the cavity (D). Scale bars represent 200 μm.