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. 2011 Aug 16;22(1):17–25. doi: 10.1111/j.1750-3639.2011.00507.x

Figure 3.

Figure 3

Increased expression of RRP22 transcripts in human malignant glioma cell lines A172 and U87MG after treatment with 5‐aza‐2′‐deoxycytidine (AZA) or trichostatin A (TSA). Real‐time RT‐PCR analysis shows increased expression of RRP22 transcripts relative to the untreated control (CTRL, cells grown under standard conditions) both when applying AZA or TSA. These findings corroborate a causal relationship between RRP22 promoter hypermethylation and decreased mRNA expression but also suggest histone modifications as an additional cause of RRP22 downregulation in glioma cells.