Table 1.

Mitochondrial dysfunction and associated cell death in Alzheimer's and prion diseases.

Disease	Altered Mitochondrial function					Cell Death pathway
	Respiration/ROS‐RNS	Dynamics	MAM	mtDNA	Lipid synthesis	MPTP formation	Apoptosis signalling	Mitophagy
Alzheimer's disease	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Prion disease	Hamster and mouse models	Hamster model	No	Mouse model	No	No	Yes	Mouse model

ROS/RNS = reactive oxygen species/reactive nitrogen species; MAM = mitochondrial associated membranes; mtDNA = mitochondrial DNA; MPTP= mitochondrial permeability transition pore formation.