Table 1.
Correlation of BRAF V600E status with clinical data, histology and immunohistochemical features in pleomorphic xanthoastrocytomas
| Parameter | BRAF V600E | BRAF wild type | P value |
|---|---|---|---|
| Patient age (years), median (range) (n = 49) | 21 (5–74) | 27 (18–65) | 0.06 |
| Patient sex (male, female) (n = 49) | 20, 18 | 8, 3 | 0.326 |
| Tumor location (temporal, other) (n = 43) | 23, 10 | 1, 9 | 0.0009 |
| Growth pattern (fibrillary, other) (n = 48) | 24, 13 | 6, 5 | 0.54 |
| Immunohistochemical characteristics | |||
| Synaptophysin‐positive (n = 49), n (%) | 8/38 (21) | 2/11 (18) | 0.84 |
| GFAP‐positive (n = 49), n (%) | 34/38 (94) | 11/11 (100) | 0.26 |
| CD34‐positive (n = 49), n (%) | 29/38 (76) | 3/11 (27) | 0.003 |
| pERK‐positive (n = 49), n (%) | 24/38 (63) | 9/11 (82) | 0.25 |
| p16 loss (n = 49), n (%) | 25/38 (66) | 5/11 (45) | 0.22 |
| Ki‐67‐positive (%), mean (95% CI) (n = 48) | 5.0 (2.9–7.0) | 6.1 (2.3–9.9) | 0.6 |
| Histological characteristics, n (%) | |||
| Eosinophilic granular bodies | 33/38 (87) | 8/11 (73) | 0.26 |
| Reticulin fibers | 29/38 (76) | 3/11 (27) | 0.003 |
| Lymphocytic cuffs | 10/38 (26) | 4/11 (36) | 0.52 |
| Xanthomatous tumor cells | 22/38 (58) | 7/11 (63) | 0.73 |
| Dysplastic neurons | 3/38 (8) | 0/11 (0) | 0.34 |
| Pleomorphic/multinucleated cells | 32/38 (84) | 11/11 (100) | 0.16 |
| Giant cells | 13/36 (36) | 3/9 (33) | 0.88 |
| Rosenthal fibers | 11/38 (29) | 2/11 (18) | 0.48 |
| Tumoral calcifications | 7/38 (18) | 1/11 (9) | 0.46 |
| Extensive hemosiderin deposition | 3/38 (8) | 0/11 (0) | 0.34 |
| Nuclear inclusions | 30/38 (79) | 8/11 (72) | 0.66 |
| Angiocentric growth | 4/38 (11) | 2/11 (18) | 0.5 |
| Prominent capillary network | 0/38 (0) | 0/11 (0) | 1 |
| Endothelial proliferation | 12/38 (32) | 4/11 (36) | 0.77 |
| Necrosis | 9/38 (24) | 3/11 (27) | 0.81 |
| Mitoses (at least 1 in 10 high‐power fields) | 15/38 (39) | 5/11 (45) | 0.72 |