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. 2016 Feb 22;27(1):26–35. doi: 10.1111/bpa.12347

Figure 3.

Figure 3

Proliferation activity in epilepsy specimens and controls. A. Ki‐67 immunohistochemistry at gray (NCx) ‐ white matter (WM) junction (dotted line) in MOGHE. Scale bar = 500 μm. B–G. higher magnification from white matter regions in different pathology samples and post‐mortem controls (autopsy; E). B. MOGHE; C. FCD ILAE Type I, D. temporal lobe epilepsy (TLE) with perivascular clustering of oligodendroglia‐like cells; F. DNT (WHO I°), G. oligodendroglioma (WHO II°). Scale bar in B = 20 μm, applies also to C–G. H. A statistically significant increase of Ki‐67 positive cells was detected in MOGHE compared with FCD I, TLE and autopsy controls (** = P < 0.01; *** = P < 0.001). A similar proliferation activity was encountered in DNTs (WHO I°, n.s. = not significant), whereas oligodendrogliomas (O) showed significantly higher proliferation (P < 0.001).