A, B. Only a small number of positive structures are visible with RD4 (A), whereas numerous positive structures are depicted with anti‐4R (B) (arrows indicate the gray–white matter junctions). C, D. Most of the structures recognized by anti‐4R (C) hardly show argyrophilia (D, Gallyas‐Braak). E–G. A variety of astrocytic tau lesions recognized by anti‐4R, including globular astrocytic inclusions (E), and those reminiscent of tufted astrocytes (F) and astrocytic plaques (G). H. Neuronal tau lesions are also clearly visible with anti‐4R. A–E, H. Motor cortex. F, G. Frontal cortex. Bars = 200 μm in A, B; 50 μm in C, D; 10 μm in E–H.