Table 1.
Distribution and severity of major histological findings in the studied patient
| Neuronal loss and gliosis | Tau‐positive | pTDP‐43‐positive | |||||
|---|---|---|---|---|---|---|---|
| Neurons | Astrocytes/oligodendrocytes | Threads | Neurons | Astrocytes/oligodendrocytes | Threads | ||
| Cerebral cortex | |||||||
| Frontal | 1 | 1 | 2/1 | 1 | 0 | 1/1 | 0 |
| Premotor/motor | 2 | 2 | 2/1 | 2 | 1 | 2/0 | 1 |
| Cerebral white matter | 2 | 1/1 | 1 | 0/1 | 0 | ||
| Parietal | 1 | 2 | 2/1 | 1 | 1 | 1/0 | 0 |
| Temporal | 1 | 2 | 2/1 | 1 | 1 | 2/1 | 1 |
| Transentorhinal | 2 | 2 | 2/1 | 2 | 2 | 2/0 | 2 |
| Occipital | 1 | 2 | 2/1 | 1 | 1 | 1/1 | 0 |
| Subcortical areas | |||||||
| Hippocampus (CA1‐subiculum) | 1(2) | 2(2) | 2/1(2/2) | 2 | 0(0) | 1/0(1/0) | 0 |
| Dentate gyrus | 1 | 1 | 1/0 | 1 | 1 | 0/0 | 0 |
| Amygdala | 2 | 1 | 1/1 | 1 | 1 | 1/1 | 1 |
| Basal nucleus of Meynert | 1 | 2 | 1/1 | 2 | 0 | 0/0 | 0 |
| Caudate/putamen | 1/1 | 1/1 | 2/1/2/1 | 2/2 | 1/1 | 1/1/1/1 | 0/0 |
| Globus pallidus | 1 | 1 | 1/2 | 2 | 1 | 1/1 | 0 |
| Internal capsule | 1/1 | 2 | 0/1 | 0 | |||
| Thalamus | 1 | 2 | 1/1 | 1 | 1 | 1/1 | 0 |
| Subthalamic nucleus | 2 | 1 | 1/1 | 1 | 1 | 0/0 | 0 |
| Brain stem | |||||||
| Midbrain tectum | 1 | 2 | 2/1 | 2 | 1 | 1/1 | 0 |
| Oculomotor nucleus | 1 | 2 | 2/2 | 2 | 0 | 1/1 | 1 |
| Red nucleus | 1 | 2 | 2/2 | 2 | 1 | 0/1 | 0 |
| Substantia nigra | 1 | 2 | 1/2 | 2 | 1 | 0/1 | 0 |
| Cerebral peduncle | 1 | 0/1 | 2 | 0/1 | 0 | ||
| Locus ceruleus | 2 | 2 | 0/1 | 1 | 0 | 0/1 | 0 |
| Trigeminal motor nucleus | 2 | 1 | 0/1 | 1 | 0 | 1/0 | 0 |
| Facial nucleus | 2 | 1 | 0/1 | 1 | 2 | 0/1 | 0 |
| Pontine nucleus | 0 | 1 | 1/1 | 1 | 0 | 0/0 | 0 |
| Fibers in pontine base | 0/1 | 2 | 0/0 | 0 | |||
| Hypoglossal nucleus | 2 | 0 | 0/0 | 0 | 0 | 0/0 | 0 |
| Inferior olivary nucleus | 0 | 1 | 1/1 | 1 | 1 | 1/1 | 1 |
| Cerebellum | |||||||
| Cerebellar cortex | 0 | 0 | 0/0 | 0 | 0 | 0/0 | 0 |
| Dentate nucleus | 1 | 1 | 0/0 | 1 | 0 | 0/0 | 0 |
| Cerebellar white matter | 0/0 | 1 | 0 | 0/0 | 0 | ||
| Spinal cord | |||||||
| Anterior horn | 2 | 1 | 1/0 | 1 | 1 | 1/0 | 0 |
| Intermediate area | 2 | 0 | 0/0 | 0 | 1 | 1/1 | 0 |
| Clarke's column | 1 | 0 | 0/0 | 0 | 0 | 0/0 | 0 |
| Posterior horn | 1 | 0 | 0/0 | 0 | 0 | 1/0 | 0 |
| Spinal white matter | 1/0 | 0 | 1/1 | 0 | |||
The presence and severity of the histopathological features are represented as 0 = none, 1 = minimal/mild and 2 = moderate/severe. Tau‐ and TDP‐43‐positive astrocytes and oligodendrocytes observed appeared mostly as globular astrocytic inclusions and coiled bodies, respectively.