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. 2012 Sep 21;23(2):165–177. doi: 10.1111/j.1750-3639.2012.00629.x

Figure 6.

figure

The cerebellar dentate nucleus in Huntington's disease (HD). A. Sagittal section through the right cerebellum of 82‐year‐old male control individual with no history of neuropsychiatric diseases depicting the folded dentate nucleus (DN). B. Marked neuronal loss of the DN of a 64‐year‐old male HD patient CAG‐repeats in the mutated HD allele, 41; age at HD onset, 55 years; duration of HD, 9 years; Vonsattel grade of striatal atrophy, 2; patient 3; Tables 1 and 5). Inset at top left points to surviving DN nerve cells: ballooned nerve cells with bloated cytoplasm and space‐consuming basophilic centre, peripheral displaced nucleus, Nissl material, and lipofuscin granules (arrows), extraneuronal lipofuscin granules (arrowheads). C. Considerable neuronal loss in the DN of a 61‐year‐old female HD patient (CAG‐repeats in the mutated HD allele, 45; age at HD onset, 35 years; duration of HD, 26 years; Vonsattel grade of striatal atrophy, 3; patient 2; Tables 1 and 5). Inset at top left shows remaining nerve cells: ballooned nerve cells (arrows), extraneuronal lipofuscin granules (arrowheads). D. Remaining DN nerve cell of a 70‐year‐old female HD patient (CAG‐repeats in the mutated HD allele, 44; age at HD onset, 50 years; duration of HD, 20 years; Vonsattel grade of striatal atrophy, 2; patient 4; Table 1) with a compact cytoplasmic inclusion (arrow). E. Surviving DN nerve cell of the same HD patient with granular cytoplasmic inclusions. (A–C) Aldehyde‐fuchsin Darrow red staining; (D,E) 1C2 immunostaining; 100 μm polyethylene glycol sections.