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. 2015 May 7;26(1):62–74. doi: 10.1111/bpa.12255

Figure 1.

figure

Voluntary running reduces the intensity of Aβ oligomers, Aβ burden and staining in brain sections from APPswe/PS1ΔE9 mice. A. Immunohistochemical analysis of Aβ oligomers stained using the specific antibody A11 in control (Tg) and runner (Tg runner) APPswe/PS1ΔE9 brains. B. Representative immunohistochemical analysis in brain slices from control (Tg) and runner (Tg runner) APPswe/PS1ΔE9 mice using the antibody 4G8 to analyze total Aβ deposits. C. Mean relative intensity of A11 staining. D, E. Mean area fraction positive for Aβ in the hippocampus (D) and cortex (E). Bars represent mean ± SE (n ≥ 5). *P < 0.05; **P < 0.01.