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. 2015 May 7;26(1):62–74. doi: 10.1111/bpa.12255

Figure 4.

figure

Voluntary exercise reduces astrogliosis in the brain of APPswe/PS1ΔE9 mice. A. Immunohistochemistry against GFAP in brain slices from control (Tg) and runner (Tg runner) APPswe/PS1ΔE9 mice. Right panels show full resolution images of astrocytes in both experimental groups. B, C. Analysis of the intensity GFAP staining (relative to control) in cortex (B) and hippocampus (C). D, E. Perikaryon size of glial cells in the hippocampus (D) and cortex (E). Quantification was normalized to control APPswe/PS1ΔE9 mice. Bars represent mean ± SE (n ≥ 5). *P < 0.05; **P < 0.01; ***P < 0.001.