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. 2011 Sep 16;22(2):159–174. doi: 10.1111/j.1750-3639.2011.00515.x

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© 2011 The Authors. Brain Pathology © 2011 International Society of Neuropathology

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Comparison of glioblastoma multiforme (GBM) neurosphere (NS) and adherent (Adh) primary cell lines sensitivity to natural killer (NK) and T cell lysis. Unloaded or MelanA‐loaded GBM NS and Adh cell lines obtained from the same initial tumor specimen were used as target cells against NK cells in the presence of the blocking antibody anti‐HLA‐ABC (), the lectin phytohemagglutinin (PHA) (◆); or IL2‐activated NK cells (□); or MelanA‐specific T cell effectors (). Results are representative of results obtained with four different donors for NK cell effectors and three different MelanA/HLA‐A2‐specific T cell lines. E : T ratio: 10:1. ***P < 0.01; *P < 0.05. ns = not statistically different.

Inline graphic — Comparison of glioblastoma multiforme (GBM) neurosphere (NS) and adherent (Adh) primary cell lines sensitivity to natural killer (NK) and T cell lysis. Unloaded or MelanA‐loaded GBM NS and Adh cell lines obtained from the same initial tumor specimen were used as target cells against NK cells in the presence of the blocking antibody anti‐HLA‐ABC (), the lectin phytohemagglutinin (PHA) (◆); or IL2‐activated NK cells (□); or MelanA‐specific T cell effectors (). Results are representative of results obtained with four different donors for NK cell effectors and three different MelanA/HLA‐A2‐specific T cell lines. E : T ratio: 10:1. ***P < 0.01; *P < 0.05. ns = not statistically different.