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. 2014 Oct 16;24(5):525–544. doi: 10.1111/bpa.12181

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© 2014 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The lumina of a WM (A) and a cortical (B) arteriole are approximately as wide and approximately similar amount of N3ECD is deposited in their tunica media, but the wall of the WM arteriole is almost fourfold thicker than that of the cortical arteriole because of the marked fibrosis. N3ECD is also deposited in the wall of a probable vein beside the arteriole (B). Delicate N3ECD immunopositivity is already present in the wall of a markedly thickened arteriole in the cerebral WM of an only 32‐year‐old male CADASIL patient (C). In an elderly patient, N3ECD immunopositivity is seen on capillaries in both cerebral WM (D) and cortex (E), as well as in the walls of larger leptomeningeal arteries (F).