Figure 9.

The cerebral white matter of a CARASIL patient who died at the age of 54 years shows diffuse widespread loss of myelin with preservation of U‐fibers (A). A small artery from a cerebral white matter shows irregular structure with double barreling of the thickened wall. Internal elastic lamina is multiplied (B). The wall of a medium‐sized leptomeningeal artery is markedly thickened with replacement of tunica muscularis by fibrous tissue, intimal proliferation and splitting of the internal elastic lamina. The smaller arteries beside show loose double barreling (C).