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. 2013 Mar 1;23(5):534–546. doi: 10.1111/bpa.12040

Figure 4.

figure

Immunoreactivity for nucleoporin 62 (Nup62) in anterior horn cells (AHCs) from non‐transgenic (NTG) (A–D) and mutant superoxide dismutase 1 (mSOD1) transgenic mice (E–H) aged 8, 12, 16 and 18 weeks. AHCs from NTG mice show normal smooth nuclear envelope staining for Nup62. At 8 weeks, mSOD1 transgenic mice have a smooth nuclear envelope, while mSOD1 transgenic mice aged 12–18 weeks show uneven, irregular nuclear envelope staining patterns. I. The corrected optical density (OD) values for Nup62 immunoreactivity are significantly lower in mSOD1 transgenic mice aged 12, 16, and 18 weeks compared with their NTG counterparts (P < 0.05), and show a tendency to be negatively correlated with disease progression. Scale bar: 50 μm (A–H), *P = 0.043; **P = 0.038; ***P = 0.0068; ****P = 0.048; *****P = 0.045; ******P = 0.030; *******P = 0.0022.