Table 3.
Stratified sclerotic index values within brain regions relative to total vascular profiles. Abbreviations: GM = gray matter; WM = white matter; SVD = small vessel disease; CADASIL = cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; PADMAL = pontine autosomal dominant microangiopathy and leukoencephalopathy; Swedish hMID = hereditary multi‐infarct dementia of Swedish type; HERNS = hereditary endotheliopathy with retinopathy, nephropathy, and stroke
| Frontal lobe | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of vessels measured | All vessels | Vessels ≤0.3 | Vessels >0.3 and <0.5 | Vessels ≥0.5 | ||||||||
| Group | Total | GM | WM | Total | GM | WM | Total | GM | WM | Total | GM | WM |
| Young control | 495 | 220 | 275 | 318 | 113 | 205 | 167 | 69 | 98 | 10 | 9 | 1 |
| Old control | 531 | 242 | 289 | 325 | 133 | 192 | 195 | 92 | 103 | 11 | 6 | 5 |
| SVD | 567 | 283 | 284 | 276 | 124 | 152 | 251 | 136 | 115 | 36 | 23 | 13 |
| CADASIL | 244 | 137 | 107 | 107 | 61 | 46 | 119 | 49 | 70 | 18 | 6 | 12 |
| PADMAL | 287 | 123 | 164 | 137 | 55 | 82 | 142 | 78 | 64 | 8 | 4 | 4 |
| Swedish hMID | 182 | 77 | 105 | 105 | 49 | 56 | 69 | 42 | 27 | 8 | 1 | 7 |
| HERNS | 62 | 32 | 30 | 22 | 7 | 15 | 36 | 14 | 22 | 4 | 3 | 1 |
| % of vessels measured | All vessels | Vessels ≤0.3 | Vessels >0.3 and <0.5 | Vessels ≥0.5 | ||||||||
| Group | GM | WM | Total | GM | WM | Total | GM | WM | Total | GM | WM | |
| Young control | 44.4 | 55.6 | 64.2 | 22.8 | 41.4 | 33.7 | 13.9 | 19.8 | 2.0 | 1.8 | 0.2 | |
| Old control | 45.6 | 54.4 | 61.2 | 25.0 | 36.2 | 36.7 | 17.3 | 19.4 | 2.1 | 1.1 | 0.9 | |
| SVD | 49.9 | 50.1 | 48.7 | 21.9 | 26.8 | 44.3 | 24.0 | 20.3 | 6.3 | 4.1 | 2.3 | |
| CADASIL | 56.1 | 43.9 | 43.9 | 25.0 | 18.9 | 48.8 | 20.1 | 28.7 | 7.4 | 2.5 | 4.9 | |
| PADMAL | 42.9 | 57.1 | 47.7 | 19.2 | 28.6 | 49.5 | 27.2 | 22.3 | 2.8 | 1.4 | 1.4 | |
| Swedish hMID | 42.3 | 57.7 | 57.7 | 26.9 | 30.8 | 37.9 | 23.1 | 14.8 | 4.4 | 0.5 | 3.8 | |
| HERNS | 51.6 | 48.4 | 35.5 | 11.3 | 24.2 | 58.1 | 22.6 | 35.5 | 6.5 | 4.8 | 1.6 | |
| Basal ganglia | ||||||||||||
| Number of vessels measured | All vessels | Vessels ≤0.3 | Vessels >0.3 and <0.5 | Vessels ≥0.5 | ||||||||
| Group | Total | GM | WM | Total | GM | WM | Total | GM | WM | Total | GM | WM |
| Young control | 642 | 354 | 288 | 386 | 204 | 182 | 241 | 141 | 100 | 15 | 9 | 6 |
| Old control | 513 | 250 | 263 | 316 | 143 | 173 | 186 | 100 | 86 | 11 | 7 | 4 |
| SVD | 427 | 201 | 226 | 253 | 122 | 131 | 143 | 69 | 74 | 31 | 10 | 21 |
| CADASIL | 548 | 296 | 252 | 177 | 99 | 78 | 262 | 149 | 113 | 109 | 48 | 61 |
| PADMAL | 360 | 170 | 90 | 208 | 103 | 105 | 150 | 66 | 84 | 2 | 1 | 1 |
| Swedish hMID | 351 | 194 | 157 | 182 | 95 | 87 | 140 | 84 | 56 | 29 | 15 | 14 |
| HERNS | 84 | 46 | 38 | 29 | 20 | 9 | 50 | 26 | 24 | 5 | 0 | 5 |
| % of vessels measured | All vessels | Vessels ≤0.3 | Vessels >0.3 and <0.5 | Vessels ≥0.5 | ||||||||
| Group | GM | WM | Total | GM | WM | Total | GM | WM | Total | GM | WM | |
| Young control | 55.1 | 44.9 | 60.1 | 31.8 | 28.3 | 37.5 | 22.0 | 15.6 | 2.3 | 1.4 | 0.9 | |
| Old control | 48.7 | 51.3 | 61.6 | 27.9 | 33.7 | 36.3 | 19.5 | 16.8 | 2.1 | 1.4 | 0.8 | |
| SVD | 47.1 | 52.9 | 59.3 | 28.6 | 30.7 | 33.5 | 16.2 | 17.3 | 7.3 | 2.3 | 4.9 | |
| CADASIL | 54.0 | 46.0 | 32.3 | 18.1 | 14.2 | 47.8 | 27.2 | 20.6 | 19.9 | 8.8 | 11.1 | |
| PADMAL | 47.2 | 25.0 | 57.8 | 28.6 | 29.2 | 41.7 | 18.3 | 23.3 | 0.6 | 0.3 | 0.3 | |
| Swedish hMID | 55.3 | 44.7 | 51.9 | 27.1 | 24.8 | 39.9 | 23.9 | 16.0 | 8.3 | 4.3 | 4.0 | |
| HERNS | 54.8 | 45.2 | 34.5 | 23.8 | 10.7 | 59.5 | 31.0 | 28.6 | 6.0 | 0.0 | 6.0 | |
Number of vessels measured to determine sclerosis in the regions of brain stratified for vessels with SI values of either ≤0.3, between 0.3 and 0.5, and ≥0.5. Numbers below expressed as a percent of total vessels measured. The bold % numbers indicate in range the high to low values for different groups.