Table 4.
Sclerotic index tested against various factors in regression models. Abbreviations: ANOVA P = analysis of variance probability values; SVD = small vessel disease; CADASIL = cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; PADMAL = pontine autosomal dominant microangiopathy and leukoencephalopathy; Swedish hMID = hereditary multi‐infarct dementia of Swedish type; HERNS = hereditary endotheliopathy with retinopathy, nephropathy, and stroke
| Model A | 1/external diameter | Age | Dummy tissue type | Dummy brain region | Gender | Adjusted R square | ANOVA P |
|---|---|---|---|---|---|---|---|
| Young control | 0.475*** | 0.056* | 0.059* | −0.231*** | 0.003 | 0.202 | 0.000 |
| Old control | 0.353*** | 0.066 | 0.052 | −0.081* | −0.035 | 0.123 | 0.000 |
| SVD | 0.426*** | 0.024 | −0.026 | −0.074* | −0.226*** | 0.175 | 0.000 |
| CADASIL | 0.345*** | 0.020 | −0.099** | −0.250*** | 0.009 | 0.124 | 0.000 |
| PADMAL | 0.438*** | 0.216*** | −0.077* | 0.099** | 0.229*** | 0.228 | 0.000 |
| Swedish hMID | 0.311*** | −0.309*** | −0.084* | −0.116** | 0.023 | 0.184 | 0.000 |
| Model B | 1/external diameter | Dummy tissue type | Dummy brain region | Adjusted R square | ANOVA P | ||
|---|---|---|---|---|---|---|---|
| Young control | 0.474*** | 0.059* | −0.239*** | 0.201 | 0.000 | ||
| Old control | 0.357*** | 0.050 | −0.098** | 0.119 | 0.000 | ||
| SVD | 0.393*** | −0.072* | −0.021 | 0.127 | 0.000 | ||
| CADASIL | 0.345*** | −0.099** | −0.256*** | 0.126 | 0.000 | ||
| PADMAL | 0.440*** | −0.052 | 0.101** | 0.213 | 0.000 | ||
| Swedish hMID | 0.285*** | −0.044 | −0.134** | 0.089 | 0.000 | ||
| HERNS | 0.493*** | −0.241** | 0.016 | 0.201 | 0.000 |
Model A: Predictors: (constant), gender, dummy tissue type, age, inverse external diameter, dummy brain region; dependent variable: SI. Model B: Predictors: (constant), dummy brain region, inverse external diameter, dummy tissue type; dependent variable: SI. Significance: *P < 0.05, **P < 0.01, ***P < 0.001.