Skip to main content
. 2014 Sep 5;25(2):136–145. doi: 10.1111/bpa.12169

Figure 5.

figure

The frequency of the apolipoprotein E (ApoE) ε3 allele was significantly associated with noncognitive impaired (NCI) anosmic subjects. Blood samples were taken from patients under study, and ApoE genotyping was performed as described in Methods section. Contingency analysis was performed for the distribution of frequencies of the ε3 and ε4 alleles between NCI, mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. A higher frequency of ε3 alleles, 8 over 10 alleles were found in the NCI group, whereas 3 over 6 alleles and 1 over 4 were determined for the MCI and AD group, respectively [chi‐squared (3.98; 1) P < 0.0469]. Otherwise, the ApoE ε4 allele was determined in seven subjects having anosmia and 5 over 10 also showed cognitive deficit or presumptive diagnosis of AD.