Table 1.
Differentially expressed genes in the cerebral cortex and hippocampus of Ts1Cje mice at Benjamini‐Hochberg false discovery rate <20%. Abbreviations: *C = cortex; H = hippocampus; WT = wild‐type
| Symbol | Gene name | Ratio cortex DS/WT | Ratio hippocampus DS/WT | Chr | Significant in* | Gene copies |
|---|---|---|---|---|---|---|
| Dnahc11 | Dynein, axonemal, heavy chain 11 | 7.34 | 8.70 | 12 | C,H | Rearranged |
| Sod1 | Superoxide dismutase 1, soluble | 1.54 | 1.67 | 16 | H | 3/1 non‐functional |
| Mrps6 | Mitochondrial ribosomal protein S6 | 1.47 | 1.20 | 16 | H | 3 |
| Ets2 | E26 avian leukemia oncogene 2, 3′ domain | 1.47 | 1.35 | 16 | H | 3 |
| Wrb | Tryptophan rich basic protein | 1.43 | 1.36 | 16 | H | 3 |
| Ifngr2 | Interferon gamma receptor 2 | 1.42 | 1.28 | 16 | H | 3 |
| Dscam | Down syndrome cell adhesion molecule | 1.40 | 1.39 | 16 | H | 3 |
| Ifnar1 | Interferon (alpha and beta) receptor 1 | 1.40 | 1.38 | 16 | H | 3 |
| Cryzl1 | Crystallin, zeta (quinone reductase)‐like 1 | 1.39 | 1.38 | 16 | H | 3 |
| Dscr3 | Down syndrome critical region gene 3 | 1.38 | 1.39 | 16 | H | 3 |
| Brwd1 | Bromodomain and WD repeat domain containing 1 | 1.36 | 1.33 | 16 | H | 3 |
| Son | Son DNA binding protein | 1.36 | 1.36 | 16 | H | 3 |
| Rcan1 | Regulator of calcineurin 1 | 1.36 | 1.31 | 16 | C,H | 3 |
| Synj1 | Synaptojanin 1 | 1.35 | 1.33 | 16 | C,H | 3 |
| 1110004E09Rik | RIKEN cDNA 1110004E09 gene | 1.33 | 1.28 | 16 | H | 3 |
| Dopey2 | Dopey family member 2 | 1.32 | 1.31 | 16 | H | 3 |
| Itsn1 | Intersectin 1 (SH3 domain protein 1A) | 1.31 | 1.33 | 16 | H | 3 |
| Gart | Phosphoribosylglycinamide formyltransferase | 1.30 | 1.23 | 16 | C,H | 3 |
| Urb1 | URB1 ribosome biogenesis 1 homolog (S. cerevisiae) | 1.29 | 1.29 | 16 | H | 3 |
| Hunk | Hormonally upregulated Neu‐associated kinase | 1.29 | 1.31 | 16 | H | 3 |
| Dyrk1a | Dual‐specificity tyrosine‐(Y)‐phosphorylation regulated kinase 1a | 1.19 | 1.27 | 16 | C,H | 3 |
| Scaf4 | SR‐related CTD‐associated factor 4 | 1.19 | 1.28 | 16 | H | 3 |
| Pcp4 | Purkinje cell protein 4 | 1.10 | 1.21 | 16 | H | 3 |
| Cyb5r1 | Cytochrome b5 reductase 1 | 1.19 | 1.16 | 1 | C | 2 |
| Snd1 | Staphylococcal nuclease and tudor domain containing 1 | 1.05 | 0.93 | 6 | H | 2 |
| Vmn2r110 | Vomeronasal 2, receptor 110 | 0.95 | 1.43 | 17 | H | 2 |
| Dcaf7 | DDB1 and CUL4 associated factor 7 | 0.95 | 0.89 | 11 | H | 2 |
| Zhx2 | Zinc fingers and homeoboxes 2 | 0.93 | 0.86 | 15 | H | 2 |
| Fsbp | Fibrinogen silencer binding protein | 0.90 | 1.50 | 4 | H | 2 |
| Tmem196 | Transmembrane protein 196 | 0.63 | 0.75 | 12 | C,H | 1 |
| Itgb8 | Integrin beta 8 | 0.57 | 0.57 | 12 | H | 1 |
Thirty‐one genes are significantly differentially expressed by ANOVA (BH‐FDR < 20%) (seven in cortex, 30 in hippocampus, six in both). Among these genes, 22 are present in three copies. Data are represented with the fold change in Ts1Cje compared with WT littermate controls.