Table 3.

Functional analysis using DAVID on the top 1% differentially expressed genes for cerebral cortex and hippocampus in Ts1Cje mice

Term	Category	Count in cortex	Count in hippocampus
Upregulated terms
GO:0010033∼Response to organic substance	GOTERM_BP_FAT	11	11
GO:0004904∼Interferon receptor activity	GOTERM_MF_FAT	2	2
GO:0019961∼Interferon binding	GOTERM_MF_FAT	2	2
mmu04630:Jak‐STAT signaling pathway	KEGG_PATHWAY	8	6
mmu04650:Natural killer cell mediated cytotoxicity	KEGG_PATHWAY	6	6
PIRSF018583:Interleukin‐10 receptor beta chain	PIR_SUPERFAMILY	2	2
Ribosome	SP_PIR_KEYWORDS	3	3
Downregulated terms
GO:0006412∼Translation	GOTERM_BP_FAT	8	9
GO:0007166∼Cell surface receptor linked signal transduction	GOTERM_BP_FAT	43	34
GO:0007186∼G‐protein coupled receptor protein signaling pathway	GOTERM_BP_FAT	40	27
GO:0007600∼Sensory perception	GOTERM_BP_FAT	32	23
GO:0007606∼Sensory perception of chemical stimulus	GOTERM_BP_FAT	30	21
GO:0007608∼Sensory perception of smell	GOTERM_BP_FAT	30	21
GO:0050877∼Neurological system process	GOTERM_BP_FAT	34	25
GO:0050890∼Cognition	GOTERM_BP_FAT	32	23
GO:0005840∼Ribosome	GOTERM_CC_FAT	7	9
GO:0003735∼Structural constituent of ribosome	GOTERM_MF_FAT	7	8
GO:0004984∼Olfactory receptor activity	GOTERM_MF_FAT	30	21
GO:0005198∼Structural molecule activity	GOTERM_MF_FAT	10	11
mmu03010:Ribosome	KEGG_PATHWAY	5	6
G‐protein coupled receptor	SP_PIR_KEYWORDS	30	20
Receptor	SP_PIR_KEYWORDS	46	28
Ribonucleoprotein	SP_PIR_KEYWORDS	6	8
Ribosomal protein	SP_PIR_KEYWORDS	7	9
Transducer	SP_PIR_KEYWORDS	30	20
Transmembrane	SP_PIR_KEYWORDS	54	54
Disulfide bond	UP_SEQ_FEATURE	20	24

Only terms with a P‐value < 0.05 in both tissues are shown. Counts indicate the number of genes for a functional term in the top 1% regulated genes.