Table 3.
Correlations between MMSE decline and pathology scores in PDD and DLB patients in BA9 (prefrontal cortex), BA21, 22 (temporal lobe neocortex with the superior and middle temporal gyrus), BA24 (anterior cingulate cortex) and BA40 (inferior parietal lobe neocortex)
(A) | n | PSS | α‐Synuclein | Plaques | Tangles | |
---|---|---|---|---|---|---|
BA9 | PDD + DLB | 65–68 | 0.343 | 0.45 | 0.053 | 0.264 |
PDD | 30–32 | 0.509 | 0.501 | 0.303 | 0.291 | |
DLB | 35–37 | 0.176 | 0.333 | −0.139 | 0.183 | |
BA21 | PDD + DLB | 65–69 | 0.406 | 0.467 | 0.231 | 0.291 |
PDD | 28–32 | 0.358 | 0.156 | 0.359 | 0.302 | |
DLB | 36–37 | 0.423 | 0.577 | 0.127 | 0.217 | |
BA24 | PDD + DLB | 64–68 | 0.227 | 0.315 | 0.142 | 0.139 |
PDD | 32 | 0.255 | 0.109 | 0.255 | 0.268 | |
DLB | 32–36 | 0.132 | 0.258 | 0.129 | 0.036 | |
BA40 | PDD + DLB | 65–69 | 0.389 | 0.475 | 0.067 | 0.283 |
PDD | 29–32 | 0.441 | 0.309 | 0.370 | 0.186 | |
DLB | 36–37 | 0.273 | 0.474 | −0.105 | 0.272 | |
(B) | n | Αβ42 | Αβ40 | Ratio Aβ42:Aβ40 | ||
BA9 | PDD + DLB | 69 | 0.385 | 0.314 | 0.340 | |
PDD | 32 | 0.407 | 0.345 | 0.45 | ||
DLB | 37 | 0.373 | 0.21 | 0.24 | ||
BA21 | PDD + DLB | 68 | 0.409 | 0.088 | 0.240 | |
PDD | 31 | 0.450 | 0.126 | 0.290 | ||
DLB | 37 | 0.307 | 0.099 | 0.09 |
(A) Correlation (Rs) of pathology summary scores and individual pathology scores with MMSE decline per year. PSS is the summation of α‐synuclein, plaque and tangle scores.
(B) Correlation (Rs) of Aβ40 and Aβ42 enzyme‐linked immunosorbent assay data with MMSE decline per year.
Values are Rs and those indicated in large bold italics indicate statistically significant correlations (P < 0.05) between that variable and MMSE decline.
Abbreviations: DLB = dementia with Lewy bodies; MMSE = Mini Mental State Examination; PDD = Parkinson's disease dementia; PSS = pathology summation score.