Table 4.
The serious AEs reported by FDA-approved package inserts of contemporary hormonal female contraceptives and the serious AEs assessed to be possibly or probably related to the male injectable contraceptive. The number of female participants that reported each AE was not reported.
| SERIOUS ADVERSE EVENTS | ||
|---|---|---|
| Contraceptive | Reported Serious AEs | Publication |
| COC | Depression, pulmonary embolism, toxic skin eruption, uterine leiomyoma. | Yasmin (2017) |
| COC | Migraine, cervical dysplasia. | Yaz (2017) |
| COC | Carcinoma of the cervix in situ, and cervical dysplasia. | Ortho Tri-Cyclen Lo (2019) |
| COC | Breast cancer, carcinoma of the cervix in situ, Hypertension, and migraine. |
Ortho Tri-Cyclen (2019) |
| IUS | Group A streptococcal sepsis. | Mirena (2017) |
| Vaginal Ring | Deep vein thrombosis, anxiety, cholelithiasis, vomiting. | NuvaRing® (2017) |
| Injectable Combination Male Contraceptive | Depression, Intentional paracetamol overdose, tachycardia with paroxysmal atrial fibrillation. | Behre et al 2016 |