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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Horm Metab Res. 2020 Mar 30;52(6):427–434. doi: 10.1055/a-1128-0421

Figure 1.

Figure 1.

Steroidogenic pathways related to the production of aldosterone, cortisol and hybrid adrenal steroids. ZG, zona glomerulosa; ZF, zona fasciculata; StAR, steroidogenic acute regulatory protein; CYP11A1, cholesterol side-chain cleavage; CYP17A1, 17α-hydroxylase; HSD3B2, 3β-hydroxysteroid dehydrogenase type 2; CYP21A2, 21-hydroxylase; CYP11B1, 11β-hydroxylase; CYP11B2, aldosterone synthase; 17OH-Prog, 17-hydroxyprogesterone; 18OH-Cortisol, 18-hydroxycortisol; APCC, aldosterone-producing cell clusters; APA, aldosterone-producing adenoma; mKCNJ5, mutant KCNJ5