Table 1.
Clinicopathological relationships.
| Clinical phenotype | Pathology (type and subtype) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Tau | TDP‐43 | FUS | |||||||
| A | B | C | D | aFTLD‐U | NIFID | BIBD | |||
| bvFTD | NFT | PB | NCI/DN | NCI | – | NII | NCI/NII | NCI | NCI |
| bvFTD/ALS | – | – | – | NCI | – | – | – | – | – |
| PNFA | – | PB | NCI/DN | – | – | – | – | – | – |
| SD | – | – | – | – | DN | – | – | – | – |
bvFTD = behavioral variant frontotemporal dementia; ALS = Amyotrophic Lateral Sclerosis; PNFA = Progressive Non‐Flent Aphasia; SD = Semantic dementia; aFTLD‐U = atypical FTLD‐U; NIFID = Neuronal Intermediate Filament Inclusion Body Disease; BIBD = Basophilic Inclusion Body Disease; NFT = neurofibrillary tangles; PB = Pick bodies; NCI = neuronal cytoplasmic inclusions; DN = dystrophic neurites; NII = neuronal intranuclear inclusions.