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. 2021 Mar 29;7(4):512–533. doi: 10.1021/acscentsci.1c00120

Table 9. Most Notable Journal Publications Related to COVID-19 Vaccines.

paper title journal key feature
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals146 Cell (May 20, 2020) identified and quantified circulating SARS-CoV-2-specific CD8+ and CD4+ T cells in ∼70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to the viral S protein were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers.
Development of an inactivated vaccine candidate for SARS-CoV-2147 Science (July 3, 2020) inactivated SARS-CoV-2 virus vaccine, PiCoVacc, against SARS-CoV-2 strain in mice, rats, and nonhuman primates
Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice148 Nature Communications (July 9, 2020) mRNA vaccine encoding the SARS-CoV-2 S protein encapsulated in a lipid nanoparticle
An mRNA vaccine against SARS-CoV-2 - preliminary report57 The New England Journal of Medicine (July 14, 2020) results from a Phase 1 clinical trial for Moderna vaccine, mRNA-1273, in three different doses
Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomized, double-blind, placebo-controlled, Phase 2 trial149 Lancet (July 20, 2020) single-dose, nonreplicating adenovirus vector vaccine expressing the full-length SAR-CoV-2 S protein gene
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques129 Nature (July 30, 2020) preclinical study on immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccine expressing the SARS-CoV-2 S protein in nonhuman primates
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity150 Nature (July 29, 2020) recombinant protein subunit vaccine tested in nonhuman primates
A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice151 Immunity (July 30, 2020) two mRNA-LNP vaccines encoding: (1) the full-length SARS-CoV-2 S protein with deleted furin cleavage site and (2) receptor-binding site of the S protein, respectively
A universal design of beta-coronavirus vaccines against COVID-19, MERS, and SARS152 Cell (August 6, 2020) structure-guided design of protein subunit vaccine composed of tandem repeat single-chain dimer of the RBD of coronavirus
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge153 Nature Communications (August 14, 2020) nonreplicating human adenovirus vector-based vaccine encoding SARS-CoV-2 S protein (Ad5-nCoV) tested in mice
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters132 Nature Medicine (September 3, 2020) adenovirus vector-based vaccine expressing a stabilized SARS-CoV-2 S protein
Safety and immunogenicity of two RNA-based Covid-19 vaccine candidates58 The New England Journal of Medicine (October 14, 2020) nucleotide-modified (1-methylpseudouridine) mRNA vaccine by Pfizer/BioNTech encoding the SARS-CoV-2 S protein
A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone112 Nature (October 23, 2020) two nanoparticle platforms, lumazine synthase and ferritin, for the display of trimeric viral protein immunogens using the SpyTag:SpyCatcher system with added N-linked glycosylation sites to nanoparticle monomers to allow the production of the specified nanoparticles in mammalian cell culture
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity154 Cell (November 12, 2020) a combined examination of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects
Eliciting B cell immunity against infectious diseases using nanovaccines155 Nature Nanotechnology (November 16, 2020) review of nanovaccine transport, localization, and antibody responses as well as its promises and challenges
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomized controlled trials in Brazil, South Africa, and the UK156 Lancet (December 8, 2020) evaluated the safety and efficacy of the adenovirus-vectored vaccine (AZD1222) expressing the SARS-CoV-2 S protein in a pooled interim analysis of four trials
Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine62 The New England Journal of Medicine (December 10, 2020) result from a multinational, randomized, placebo-controlled, observer-blinded clinical trial for a two-dose regimen of BNT162b2
Safety and efficacy of the mRNA-1273 SARS-CoV-2 vaccine61 The New England Journal of Medicine (December 30, 2020) result from the Phase 3 randomized, observed-blinded, placebo-controlled clinical trial of mRNA-1273 conducted in the U.S.
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection157 Science (February 5, 2021) assessed multiple compartments of circulating immune memory to SARS-CoV-2 in hundreds of COVID-19 cases
Safety and immunogenicity of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19 in healthy adults: a phase 1, randomized, double-blind, placebo-controlled trial158 Lancet (February 2021) reported vaccine SCB-2019 developed by Clover Biopharmaceuticals which contains a stabilized trimeric form of the S protein combined with two different adjuvants
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7141 Nature (March 8, 2021) tested the effectiveness of neutralizing antibodies and mRNA vaccines mRNA-1273 and BNT162b2 against two SARS-CoV-2 variants