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Cell (May 20, 2020) |
identified and quantified circulating SARS-CoV-2-specific CD8+ and CD4+ T cells in ∼70% and 100% of COVID-19 convalescent
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Development of an inactivated
vaccine candidate for SARS-CoV-2147
|
Science (July
3, 2020) |
inactivated SARS-CoV-2 virus vaccine, PiCoVacc, against SARS-CoV-2 strain in mice, rats, and nonhuman primates |
Self-amplifying RNA SARS-CoV-2 lipid
nanoparticle vaccine candidate induces high neutralizing antibody
titers in mice148
|
Nature Communications (July 9, 2020) |
mRNA vaccine encoding the SARS-CoV-2 S protein encapsulated in a lipid
nanoparticle |
An mRNA vaccine against SARS-CoV-2 - preliminary report57
|
The New
England Journal of Medicine (July 14, 2020) |
results from a Phase 1 clinical trial
for Moderna vaccine, mRNA-1273, in three different doses |
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type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or
older: a randomized, double-blind, placebo-controlled, Phase 2 trial149
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Lancet (July
20, 2020) |
single-dose, nonreplicating adenovirus vector
vaccine expressing the full-length SAR-CoV-2 S protein gene |
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques129
|
Nature (July 30, 2020) |
preclinical study on immunogenicity and protective efficacy of a
single dose of adenovirus serotype 26 (Ad26) vector-based vaccine
expressing the SARS-CoV-2 S protein in nonhuman primates |
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity150
|
Nature (July 29, 2020) |
recombinant
protein subunit vaccine tested in nonhuman primates |
A single immunization with nucleoside-modified mRNA vaccines
elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice151
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Immunity (July 30, 2020) |
two mRNA-LNP vaccines encoding: (1)
the full-length SARS-CoV-2 S protein with deleted furin cleavage site and (2)
receptor-binding site of the S protein, respectively |
A universal design of beta-coronavirus
vaccines against COVID-19, MERS, and SARS152
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Cell (August 6, 2020) |
structure-guided design of protein subunit vaccine composed of tandem
repeat single-chain dimer of the RBD of coronavirus |
A single dose of an adenovirus-vectored vaccine provides protection
against SARS-CoV-2 challenge153
|
Nature
Communications (August 14, 2020) |
nonreplicating
human adenovirus vector-based vaccine encoding SARS-CoV-2 S protein (Ad5-nCoV) tested in mice |
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters132
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Nature Medicine (September 3, 2020) |
adenovirus vector-based vaccine
expressing a stabilized SARS-CoV-2 S protein |
Safety and immunogenicity of two RNA-based
Covid-19 vaccine candidates58
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The New England Journal of
Medicine (October 14, 2020) |
nucleotide-modified
(1-methylpseudouridine) mRNA vaccine by Pfizer/BioNTech encoding the SARS-CoV-2 S protein |
A platform incorporating trimeric antigens
into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing
responses than spike alone112
|
Nature (October 23,
2020) |
two nanoparticle platforms, lumazine synthase
and ferritin, for the display of trimeric viral protein immunogens
using the SpyTag:SpyCatcher system with added N-linked
glycosylation sites to nanoparticle monomers to allow the production
of the specified nanoparticles in mammalian cell culture |
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Cell (November
12, 2020) |
a combined examination of SARS-CoV-2-specific CD4+ and CD8+ T cell and
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Eliciting B cell immunity
against infectious diseases using nanovaccines155
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Nature
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review of
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controlled trials in Brazil, South Africa, and the UK156
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Lancet (December 8, 2020) |
evaluated the safety
and efficacy of the adenovirus-vectored vaccine (AZD1222) expressing
the SARS-CoV-2 S protein in a pooled interim analysis of four trials |
Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine62
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The New England Journal of Medicine (December 10,
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result from a multinational, randomized, placebo-controlled,
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The New England Journal of Medicine (December 30,
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result from the Phase 3 randomized, observed-blinded, placebo-controlled clinical trial
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Immunological
memory to SARS-CoV-2 assessed for up
to 8 months after infection157
|
Science (February
5, 2021) |
assessed multiple compartments of circulating
immune memory to SARS-CoV-2 in hundreds
of COVID-19 cases |
Safety and immunogenicity
of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19
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Lancet (February 2021) |
reported vaccine SCB-2019 developed by Clover Biopharmaceuticals
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with two different adjuvants |
Antibody Resistance
of SARS-CoV-2 Variants B.1.351 and
B.1.1.7141
|
Nature (March 8, 2021) |
tested the effectiveness of neutralizing
antibodies and mRNA vaccines mRNA-1273 and BNT162b2 against two SARS-CoV-2 variants |