Skip to main content
. Author manuscript; available in PMC: 2023 Sep 6.
Published in final edited form as: ACS Chem Neurosci. 2021 Mar 31;12(8):1299–1312. doi: 10.1021/acschemneuro.0c00619

Figure 2. Chemical structures of the top 20 hits.

Figure 2.

Compounds are grouped by common core motif, shown in magenta. Molecules that adopt binding Mode II (9, 9a, 14, 17, 18, 16, 19, 20) have the atoms that form potential hydrogen bonds with Asp320, E319, or G318 colored in blue. The common 2(1H)-pyridone core is highlighted with a gray box in structure 15.