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. Author manuscript; available in PMC: 2023 Sep 6.
Published in final edited form as: ACS Chem Neurosci. 2021 Mar 31;12(8):1299–1312. doi: 10.1021/acschemneuro.0c00619

Figure 3. NRP-1 hydrophobic box.

Figure 3.

The hydrophobic groove formed by residues Tyr297, Tyr253, Trp301, and Thr316 are shown as gray spheres. Compound 1 is shown as green sticks and contacts with hydrophobic box residues within 5 Å shown as dashes. Remaining binding site residues colored red if acidic, yellow if polar, and gray if hydrophobic.