Table 2.
Distribution of AT8‐positive NFTs in all AGD cases.
| Neurofibrillary tangles | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Braak NFT stage*/Thal Aβ phase | Lewy body disease subtype | Argyrophilic grain disease stage | TDP‐43 pathology | Superior frontal cortexb | Caudate nucleus | Putamen | Globus pallidus | Subthalamic nucleus | Substantia nigra | Oculomotor nucleus | Pontine nucleus | Inferior olivary nucleus | Dentate nucleus in cerebellum | |
| AGD 1 | II/5 | 0 | I | 0 | n.e. | − | − | − | − | − | − | − | − | − |
| AGD 2 | II/0 | 0 | I | 0 | − | − | − | − | − | − | − | − | − | − |
| AGD 3 | I/0 | Limbic type | I | 0 | + | − | − | − | − | − | − | − | − | − |
| AGD 4 | I/0 | 0 | II | 0 | + | − | − | − | +++ | +++ | +++ | − | − | + |
| AGD 5 | II/0 | 0 | II | 0 | − | − | +++ | +++ | ++++ | ++ | +++++ | − | − | − |
| AGD 6 | II/4 | 0 | II | 0 | n.e. | +++ | +++ | +++++ | ++++ | ++++ | +++++ | +++ | − | − |
| AGD 7 | II/2 | 0 | I | Temporal type | +++ | +++ | +++ | +++ | n.a. | +++ | ++ | +++ | − | − |
| AGD 8 | 0/0 | 0 | II | 0 | + | ++++ | ++++ | ++++ | n.a. | ++++ | +++++ | ++++ | − | − |
| (%) | 66.7 | 37.5 | 50.0 | 50.0 | 50.0 | 62.5 | 62.5 | 37.5 | 0.0 | 12.5 | ||||
a
Braak NFT stage determined on sections stained with RD3 is shown.
b
The number of NFTs in the superior frontal cortex was assessed when the case did not have Aβ deposits in the region. Semiqunatitative NFT stages 0 to 7 correspond to – to +++++++ (see text). n.e. = not examined; n.a. = not available.