Table 4.
Distribution of TAs and tau‐positive astrocytic lesions in all AGD‐TA cases.
| Quantity of Gallyas‐positive TAs | Quantity of tau (AT8)‐positive astrocytic lesions* | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Frontal cortex † | Caudate nucleus | Putamen | Globus pallidus | Subthalamic nucleus | Substantia nigra | Oculomotor nucleus | Pontine nucleus | Inferior olivary nucleus | Dentate nucleus in cerebellum | Frontal cortex† | Putamen | Putamen | Globus pallidus | Subthalamic nucleus | Substantia nigra | Oculomotor nucleus | Pontine nucleus | Inferior olivary nucleus | Dentate nucleus in cerebellum | ||
| AGD‐TA | AGD‐TA 1 | − | − | − | − | − | − | − | − | − | − | − | ++ | − | − | − | − | − | − | − | − |
| having | AGD‐TA 2 | − | − | − | − | n.a. | − | − | − | − | − | ++ | − | ++ | ++ | n.a. | − | − | + | − | − |
| only | AGD‐TA 3 | n.e. | − | − | − | n.a. | − | − | − | − | − | n.e. | − | +++ | − | n.a. | − | + | − | − | − |
| TAIs | AGD‐TA 4 | − | − | − | − | n.a. | − | − | − | − | − | +++ | − | + | + | n.a. | − | − | − | − | − |
| AGD‐TA 5 | − | − | − | − | − | − | − | − | − | − | − | + | + | − | − | − | − | − | − | − | |
| AGD‐TA 6 | n.e. | − | − | − | − | − | − | − | − | − | n.e. | ++ | − | − | − | − | − | − | − | − | |
| % | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 50.0 | 50.0 | 66.7 | 33.3 | 0.0 | 0.0 | 16.7 | 16.7 | 0.0 | 0.0 | |
| AGD‐TA | AGD‐TA 7 | n.e. | − | ++ | − | − | − | − | − | +++ | − | n.e. | +++ | ++ | ++ | ++ | − | ++ | − | ++ | − |
| having | AGD‐TA 8 | ++ | ++++ | ++++ | − | − | − | − | − | + | − | ++ | ++++ | ++++ | − | − | − | +++ | − | + | − |
| both TAs | AGD‐TA 9 | +++ | − | ++ | − | − | − | − | − | − | − | +++ | ++ | ++ | ++ | ++ | − | − | − | − | − |
| and TAIs | AGD‐TA 10 | n.e. | − | − | − | − | − | − | − | ++ | − | n.e. | +++ | +++ | ++ | ++ | − | ++ | ++ | ++ | − |
| AGD‐TA 11 | ++ | − | − | − | − | − | − | − | − | − | +++ | +++ | +++ | − | +++ | ++ | + | + | ++ | − | |
| % | 100 | 20.0 | 60.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 60.0 | 0.0 | 100 | 100 | 100 | 60.0 | 80.0 | 20.0 | 80.0 | 40.0 | 80.0 | 0.0 | |
a
In AGD‐TA 1–6, the number of AT8‐positive astrocytic lesions shown in this table is that of TAIs, because these cases lacked TAs. In AGD‐TA 7–11, AT8‐positive astrocytic lesions may include both TAIs and TAs because these lesions cannot be completely differentiated by AT8 immunohistochemistry. n.e. = not examined; n.a. = not available. Semiquanatitative TA stages 0 to 6 correspond to – to ++++++ (see text).
†The number of TAs and tau‐positive astrocytic lesions in the superior frontal cortex was assessed when the case did not have Aβ deposits in the region. None of subjects had neuritic plaques in other regions examined.