Table 1.

Clinical and genetic profile of the gliosarcoma and the giant cell glioblastoma, in comparison with primary and secondary glioblastoma.

	Primary glioblastoma (IDH wild‐type)	Gliosarcoma	Giant cell glioblastoma	Secondary glioblastoma (IDH mutant)
Age at GBM diagnosis	59 years [Link] , [Link] , [Link] , [Link]	56 years 5	44 years [Link] , [Link]	43 years [Link] , [Link] , [Link] , [Link]
Sex ratio M/F	1.4 [Link] , [Link]	1.4 5	1.6 6	1.0 [Link] , [Link]
Clinical history	3.9 months 1	3.0 months 5	1.6 months 6	15.2 months 1
IDH1/2 mutation	0% [Link] , [Link] , [Link]	0% *	5% *	100% [Link] , [Link] , [Link]
PTEN mutation	24% [Link] , [Link] , [Link]	41% [Link] , [Link]	33% 6	5% [Link] , [Link] , [Link]
ATRX expression loss	0% 11	0% *	19% *	100% 11
TERT mutation	72% [Link] , [Link] , [Link]	83% *	25% *	26% [Link] , [Link] , [Link]
TP53 mutation	23% [Link] , [Link] , [Link]	25% [Link] , [Link]	84% [Link] , [Link] , [Link]	74% [Link] , [Link] , [Link]
LOH 19q	4% 1	18% *	42% *	32% 1
EGFR amplification	42% [Link] , [Link] , [Link]	5% 5,10	6% [Link] , [Link] , [Link]	4% [Link] , [Link] , [Link]
p16INK4a deletion	45% [Link] , [Link] , [Link]	37% 5	3% [Link] , [Link]	30% [Link] , [Link] , [Link]
LOH 1p	15% 1	6% *	17% *	24% 1
LOH 1p/19q	2% 1	6% *	17% *	11% 1
LOH 10q	67% 1	88% *	50% *	73% 1

^*This study.

¹Nobusawa et al 24.

²Bleeker et al 5.

³Ichimura et al 12.

⁴Reuss et al 32.

⁵Reis et al 31.

⁶Peraud et al 30.

⁷Meyer‐Puttlitz et al 18.

⁸Gao et al 11.

⁹Cerami et al 9.

¹⁰Actor et al 1.

¹¹Liu et al 14.

¹²Nonoguchi et al 25.

¹³Eckel‐Passow et al 10.

¹⁴Brennan et al 8.

¹⁵Martinez et al 17.

        Typical for primary glioblastomas

        Typical for secondary glioblastomas