Table 4.

Mixed general linear model of the association between different CGM variables (the dependent variables) and CPAP treatment vs control (univariate analysis) with baseline values of Hba1c, AHI, BMI and dependent variable as covariates (multiple analysis) in 58 patients with type 2 diabetes and obstructive sleep apnoea randomized to CPAP or not CPAP for 12 wks

Variable	Regression coefficient (95% CI)	P‐value	Regression coefficient (95% CI)	P‐value
	Effect of CPAP vs control control = reference		Effect of CPAP vs control adjusted for baseline Hba1c, AHI, BMI and dependent variable Control = reference
All 58 participants
Average CGM glucose, 24 h (mmol/L)	−0.7 (−1.8 to 0.4)	.22	−0.8 (−1.7 to 0.2)	.10
Average CGM glucose night (mmol/L)	−0.7 (−1.8 to 0.4)	.21	−0.5(−1.5 to 0.4)	.27
Average CGM glucose day (mM)	−0.7 (−1.8 to 0.5)	.25	−0.9 (−1.9 to 0.1)	.08
Time in range (3.9‐10.0 mmol/L; %)
24 h	+6.6 (−6.2 to 19.3)	.31	+ 9.2 (−2.6 to 21.0)	.12
Night	+6.9 (−6.3 to 20.1)	.30	+ 5.5 (−7.0 to 18.0)	.38
Day	+6.3 (−7.8 to 20.4)	.37	+ 10.8 (−2.0 to 23.6)	.10
Glycaemic variability, coefficient of variation	−0.008 (−0.05 to 0.03)	.69	−0.005 (−0.03 to 0.04)	.77
dCPAP noncompliant participants excluded
Average CGM glucose, 24 h (mmol/L)	−1.0 (−2.3 to 0.4)	.15	−0.5 (−1.7 to 0.7)	.40
Average CGM glucose night (mmol/L)	−1.2 (−2.6 to 0.1)	.07	−0.1 (−1.2 to 1.0)	.86
Average CGM glucose day (mmol/L)	−0.9 (−2.2 to 0.5)	.21	−0.6 (−1.9 to 0.6)	.30
Time in range (3.9‐10.0 mmol/L; %)
24 h	+11.7 (−3.4 to 26.7)	.13	+ 8.8 (−5.7 to 23.3)	.23
Night	+14.7 (−1.8 to 31.2)	.08	+ 3.3 (−11.8 to 18.4)	.66
Day	+10.2 (−6.0 to 26.4)	.21	+ 11.1 (−4.4 to 26.6)	.16
Glycaemic variability, coefficient of variation	−0.011 (−0.06 to 0.04)	.64	−0.008 (−0.06 to 0.04)	.73

In the lower part of the table, CPAP noncompliant participants are excluded leaving 16 compliant participants and 31 control participants for analysis.

Abbreviations: CGM, continuous glucose monitoring; CPAP, continuous positive airway pressure.