FIGURE 6.

Evaluation of hypoglycaemia awareness. A, Blood glucose levels during the induction of hypoglycaemia. B, Diabetic rats made hypoglycaemic (STZ+Insulin) consumed significantly (***p < 0.001) more food than hypoglycaemia‐naïve rats given a saline injection (STZ+Saline). Diabetic rats treated with 2‐deoxyglucose (STZ+2DG) consumed significantly less food when hypoglycaemic compared to the STZ+Insulin group (***p < 0.001, 2DG+Insulin vs Saline+Insulin). Although treatment with 4.5 mg/kg carvedilol increased food consumption in STZ+2DG diabetic animals, the increase did not reach statistical significance. In contrast, when the STZ+2DG animals were treated with 6 mg/kg carvedilol, the animals consumed more food than the STZ+2DG group (*p < 0.05). Data presented as mean ± SEM