Table 1.
Peptide hormones catabolized by neprilysin and their effects on blood pressures
Name | Actions | Effect on blood pressures | Effect by valsartan |
---|---|---|---|
Adrenomedullin | Systemic vasodilation and new angiogenesis | Decrease | Increase levels |
Angiotensin II | Systemic vasoconstriction and cardiovascular remodeling | Increase | Antagonism |
Bradykinin | Systemic vasodilation and cough stimulation | Decrease | Possibly increase levels, but generally neutral |
Endothelin‐1 | Systemic vasoconstriction | Increase | Decrease levels |
Glucagon | Released from the α cells of pancreas; glycogen catalysis and blood glucose increase | Increase | Possibly increase levels |
NPs | Systemic vasodilation; diuresis, and natriuresis | Decrease | Increase levels |
Neurotensin | Regulation of luteinizing hormone and prolactin; systemic vasodilation through interaction with the dopaminergic system | Biphasic | Unknown |
Oxytocin | Facilitation in child birth | Decrease | Possibly increase levels |
Substance P | Cough production | Decrease | Neutral |