Table 1.
Peptide hormones catabolized by neprilysin and their effects on blood pressures
| Name | Actions | Effect on blood pressures | Effect by valsartan |
|---|---|---|---|
| Adrenomedullin | Systemic vasodilation and new angiogenesis | Decrease | Increase levels |
| Angiotensin II | Systemic vasoconstriction and cardiovascular remodeling | Increase | Antagonism |
| Bradykinin | Systemic vasodilation and cough stimulation | Decrease | Possibly increase levels, but generally neutral |
| Endothelin‐1 | Systemic vasoconstriction | Increase | Decrease levels |
| Glucagon | Released from the α cells of pancreas; glycogen catalysis and blood glucose increase | Increase | Possibly increase levels |
| NPs | Systemic vasodilation; diuresis, and natriuresis | Decrease | Increase levels |
| Neurotensin | Regulation of luteinizing hormone and prolactin; systemic vasodilation through interaction with the dopaminergic system | Biphasic | Unknown |
| Oxytocin | Facilitation in child birth | Decrease | Possibly increase levels |
| Substance P | Cough production | Decrease | Neutral |