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. 2020 Dec 11;23(3):556–567. doi: 10.1111/jch.14120

Table 1.

Peptide hormones catabolized by neprilysin and their effects on blood pressures

Name Actions Effect on blood pressures Effect by valsartan
Adrenomedullin Systemic vasodilation and new angiogenesis Decrease Increase levels
Angiotensin II Systemic vasoconstriction and cardiovascular remodeling Increase Antagonism
Bradykinin Systemic vasodilation and cough stimulation Decrease Possibly increase levels, but generally neutral
Endothelin‐1 Systemic vasoconstriction Increase Decrease levels
Glucagon Released from the α cells of pancreas; glycogen catalysis and blood glucose increase Increase Possibly increase levels
NPs Systemic vasodilation; diuresis, and natriuresis Decrease Increase levels
Neurotensin Regulation of luteinizing hormone and prolactin; systemic vasodilation through interaction with the dopaminergic system Biphasic Unknown
Oxytocin Facilitation in child birth Decrease Possibly increase levels
Substance P Cough production Decrease Neutral