Table 4.

Multiple linear regression analysis of the association between cardiovascular risk markers, OH and its individual components. The values presented are means with their standard error

Blood marker	No OH (n = 3079)	COH (n = 778)	P	ISOH (n = 485)	P	IDOH (n = 177)	P	SDOH (n = 116)	P
	Mean (SE)	Mean (SE)		Mean (SE)		Mean (SE)		Mean (SE)
IL‐6, * , a pg/mL	2.40 (1.01)	2.47 (1.02)	.2983	2.40 (1.03)	.9916	2.49 (1.05)	.4406	2.74 (1.06)	.0292
Phosphate, mmol/L	1.15 (<0.01)	1.18 (0.01)	<.0001*	1.16 (0.01)	.0988	1.19 (0.01)	.0011*	1.21 (0.01)	.0001*
VWF, IU/dL	137.38 (0.80)	145.36 (1.64)	<.0001*	144.70 (2.05)	.0010*	145.46 (3.39)	.0207	148.09 (4.18)	.0122
D‐dimer, * , a ng/mL	82.73 (1.01)	86.70 (1.03)	.1499	83.92 (1.04)	.7102	85.15 (1.06)	.6362	102.82 (1.08)	.0038
NT‐proBNP, * , a pg/mL	94.85 (1.02)	101.00 (1.04)	.1285	91.86 (1.05)	.5219	108.95 (1.08)	.0828	136.09 (1.10)	.0001*
Hs‐troponin T, * , a pg/mL	11.72 (1.01)	12.12 (1.02)	.0692	12.00 (1.02)	.2983	12.42 (1.03)	.0983	12.21 (1.04)	.3399

Abbreviations: COH, consensus orthostatic hypotension; IDOH, isolated diastolic orthostatic hypotension; ISOH, isolated systolic orthostatic hypotension; SDOH, combined systolic and diastolic orthostatic hypotension.

The multiple regression models adjusted for age, body mass index, mean sitting systolic blood pressure, resting pulse, smoking status, alcohol consumption, social class, physical activity, presence of prevalent stroke, myocardial infarction, atrial fibrillation, diabetes mellitus, chronic kidney disease, chronic obstructive pulmonary disease, and current antihypertensive medication use. In all cases of hypothesis testing, “No OH” was the reference group.

^aGeometric mean (standard error); all other values are the arithmetic mean (standard error).

^*Statistically significant after Bonferroni adjustment (P < .0036).