Table 5.
Multiple linear regression sensitivity analysis of the association between cardiovascular risk markers, OH, and its individual components. The values presented are means with their standard error. The sensitivity analysis excluded 352 participants with prevalent stroke and/or myocardial infarction
| Blood marker |
No OH (n = 2795) |
COH (n = 710) |
P |
ISOH (n = 450) |
P |
IDOH (n = 155) |
P |
SDOH (n = 105) |
P |
|---|---|---|---|---|---|---|---|---|---|
| Mean (SE) | Mean (SE) | Mean (SE) | Mean (SE) | Mean (SE) | |||||
| Phosphate, mmol/L | 1.15 (<0.01) | 1.18 (0.01) | <.0001* | 1.17 (0.01) | .0341 | 1.19 (0.01) | .0057 | 1.21 (0.02) | .0002* |
| VWF, IU/dL | 135.94 (0.84) | 144.48 (1.70) | <.0001* | 143.37 (2.11) | .0012* | 146.07 (3.60) | .0062 | 147.00 (4.34) | .0128 |
| D‐dimer, a ng/mL | 79.90 (1.01) | 84.34 (1.03) | .1042 | 82.44 (1.04) | .4273 | 82.38 (1.06) | .632 | 96.75 (1.08) | .013 |
| NT‐proBNP, a pg/mL | 87.99 (1.02) | 92.36 (1.04) | .2568 | 84.94 (1.05) | .4909 | 98.64 (1.09) | .1745 | 121.99 (1.10) | .0009* |
Abbreviations: COH, consensus orthostatic hypotension; IDOH, isolated diastolic orthostatic hypotension; ISOH, isolated systolic orthostatic hypotension; SDOH, combined systolic and diastolic orthostatic hypotension.
The multiple regression models adjusted for age, body mass index, mean sitting systolic blood pressure, resting pulse, smoking status, alcohol consumption, social class, physical activity, presence of prevalent atrial fibrillation, diabetes mellitus, chronic kidney disease, chronic obstructive pulmonary disease, and current antihypertensive medication use. In all cases of hypothesis testing, “No OH” was the reference group.
Geometric mean (standard error); all other values are the arithmetic mean (standard error).
Statistically significant after Bonferroni adjustment (P < .0036).