Table 6.

Odds of consensus OH, and its components, when levels of cardiovascular risk markers are elevated (the markers were grouped into tertiles and “elevated” was defined as top tertile vs bottom tertile)

	No OH (n = 3079)	COH (n = 778)	ISOH (n = 485)	IDOH (n = 177)	SDOH (n = 116)
	Odds ratio (95% Confidence interval)
Phosphate, mmol/L	1.00	1.39 (1.13‐1.71)	1.22 (0.95‐1.57)	1.53 (1.04‐2.25)	2.12 (1.31‐3.44)
IL‐6, pg/mL	1.00	1.05 (0.84‐1.31)	0.97 (0.75‐1.27)	1.04 (0.68‐1.57)	1.51 (0.89‐2.55)
VWF, IU/dL	1.00	1.45 (1.18‐1.79)	1.35 (1.05‐1.73)	1.38 (0.92‐2.08)	2.27 (1.35‐3.83)
D‐dimer, ng/mL	1.00	1.08 (0.86‐1.35)	0.99 (0.75‐1.30)	1.22 (0.80‐1.86)	1.34 (0.79‐2.28)
NT‐proBNP, pg/mL	1.00	1.13 (0.88‐1.45)	0.97 (0.72‐1.30)	1.16 (0.72‐1.88)	2.14 (1.14‐4.03)
Hs‐troponin T, pg/mL	1.00	1.10 (0.88‐1.38)	0.99 (0.76‐1.30)	1.69 (1.07‐2.65)	0.87 (0.51‐1.50)

Abbreviations: COH, consensus orthostatic hypotension; IDOH, isolated diastolic orthostatic hypotension; ISOH, isolated systolic orthostatic hypotension; SDOH, combined systolic and diastolic orthostatic hypotension.

The cut‐offs for individual tertiles were as follows: Phosphate (mmol/L) tertile 1 (T1) < 1.10, tertile 2 (T2) ≥ 1.10 to <1.22, tertile 3 (T3) ≥ 1.22; VWF (IU/dL) T1 < 116, T2 ≥ 116 to <155, T3 ≥ 155, D‐dimer (ng/mL) T1 < 58, T2 ≥ 58 to <104, T3 ≥ 104; NT‐proBNP (pg/mL) T1 < 59, T2 ≥ 59 to <140, T3 ≥ 140, hs‐troponin T (pg/mL) T1 < 9.8, T2 ≥ 9.8 to <14.3, T3 ≥ 14.3. The odds ratios were calculated from multiple logistic regression models, which adjusted for age, body mass index, mean sitting systolic blood pressure, resting pulse, total cholesterol, smoking status, alcohol consumption, physical activity, social class and the presence of prevalent stroke, myocardial infarction, atrial fibrillation, diabetes mellitus, chronic kidney disease, and current antihypertensive medication use. In all cases, “No OH” was the reference group for hypothesis testing.