TABLE 4.

The association between dispensed drugs and the risk of heart failure in patients with atrial fibrillation in patients with and without coronary heart disease (CHD) ^a

	Men						Women
	With CHD			Without CHD			With CHD			Without CHD
	HR	95% CI		HR	95% CI		HR	95% CI		HR	95% CI
All medication	1.53	1.27	1.84	1.58	1.48	1.69	2.93	2.09	4.12	1.95	1.77	2.14
a. Loop diuretics	1.23	1.07	1.41	1.45	1.34	1.57	1.25	1.11	1.41	1.19	1.11	1.28
b. Thiazides	0.92	0.78	1.08	1.06	0.97	1.15	1.03	0.88	1.22	0.91	0.84	0.99
c. Potassium‐saving agents	1.73	1.38	2.17	1.44	1.23	1.68	1.07	0.87	1.32	1.38	1.24	1.53
d. Beta‐1‐selective beta‐blockers	0.90	0.84	0.96	0.92	0.88	0.96	0.93	0.87	1.01	0.95	0.91	0.99
e. Non‐selective beta‐blockers	0.97	0.83	1.13	0.89	0.82	0.97	0.90	0.76	1.07	0.97	0.90	1.06
f. Heart‐active calcium channel blockers	0.98	0.70	1.36	1.10	0.95	1.27	1.14	0.84	1.53	1.14	1.00	1.31
g. Vessel‐active calcium channel blockers	1.12	1.03	1.22	1.06	0.99	1.14	1.02	0.91	1.13	1.02	0.95	1.10
h. ACE inhibitors	1.15	1.07	1.23	1.28	1.22	1.35	1.13	1.03	1.24	1.28	1.21	1.36
i. ARBs	1.14	1.02	1.27	1.18	1.09	1.27	1.14	1.00	1.29	1.16	1.07	1.25
j. Statins	0.91	0.85	0.97	0.96	0.90	1.03	0.95	0.88	1.04	0.96	0.89	1.04

In the full model, we adjusted for age, region of Sweden, immigrant status, socioeconomic factors, comorbidities, and all drug classes.

Abbreviations: ARBs, angiotensin receptor blocking agents; HR, hazards ratios, CI, confidence intervals.

^aFull adjusted model.

Bold values are statistically significant.