Table 1.
Baseline clinical characteristics of study patients
| Characteristic |
Total (n = 2561) |
Event (+) (n = 69) |
Event (−) (n = 2492) |
P value |
|---|---|---|---|---|
| Age, y | 62.7 ± 11.7 | 65.8 ± 9.3 | 62.6 ± 11.8 | .007 |
| Female sex | 1202 (46.9) | 26 (37.7) | 1176 (47.2) | .118 |
| BMI, kg/m2 | 25.4 ± 3.4 | 26.0 ± 3.5 | 25.4 ± 3.4 | .147 |
| SBP, mm Hg | 138 ± 19 | 136 ± 20 | 138 ± 19 | .540 |
| DBP, mm Hg | 81.2 ± 12.1 | 79.5 ± 10.8 | 81.3 ± 12.1 | .231 |
| Heart rate, per min | 70.2 ± 12.5 | 69.7 ± 11.5 | 70.2 ± 12.5 | .724 |
| Cardiovascular risk factors | ||||
| Obesity (BMI ≥ 25 kg/m2) | 1320 (51.5) | 41 (59.4) | 1279 (51.3) | .185 |
| Diabetes mellitus | 896 (35.0) | 39 (56.5) | 857 (34.4) | <.001 |
| Dyslipidemia | 1682 (65.7) | 57 (82.6) | 1625 (65.2) | .003 |
| Cigarette smoking | 406 (15.9) | 16 (23.2) | 390 (15.7) | .091 |
| Laboratory findings | ||||
| WBC, per microliter | 7191 ± 3647 | 7557 ± 2711 | 7180 ± 3669 | .412 |
| Hemoglobin, g/dL | 13.3 ± 1.9 | 12.9 ± 2.5 | 13.3 ± 1.9 | .191 |
| GFR, mL/min/1.73 m2 | 80.7 ± 30.1 | 74.5 ± 36.8 | 80.9 ± 29.9 | .159 |
| Fasting glucose, mg/dL | 124 ± 43 | 133 ± 53 | 123 ± 42 | .146 |
| Glycated hemoglobin, % | 6.44 ± 1.12 | 6.89 ± 1.21 | 6.43 ± 1.11 | .021 |
| Total cholesterol, mg/dL | 155 ± 39 | 142 ± 36 | 155 ± 39 | .006 |
| LDL cholesterol, mg/dL | 87.8 ± 32.8 | 75.5 ± 33.6 | 88.1 ± 32.7 | .003 |
| HDL cholesterol, mg/dL | 48.9 ± 12.9 | 47.5 ± 13.9 | 48.9 ± 12.9 | .400 |
| Triglycerides, mg/dL | 129 ± 76 | 126 ± 61 | 129 ± 76 | .719 |
| C‐reactive protein, mg/dL | 1.17 ± 3.66 | 1.92 ± 4.39 | 1.15 ± 3.64 | .212 |
| Concomitant medications | ||||
| Calcium channel blocker | 979 (38.2) | 26 (37.7) | 953 (38.2) | .925 |
| Beta blocker | 800 (31.2) | 29 (42.0) | 771 (30.9) | .050 |
| RAS blocker | 1284 (50.1) | 34 (39.3) | 1250 (50.2) | .885 |
| Diuretics | 71 (2.8) | 0 | 71 (2.8) | .262 |
| Statin | 1467 (57.3) | 52 (75.4) | 1415 (56.8) | .002 |
Numbers are expressed as mean ± standard deviation or n (%).
Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; GFR, glomerular filtration rate; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; RAS, renin‐angiotensin system; SBP, systolic blood pressure; WBC, white blood cell.