Figure 3.

Proposed simplified circuit of internal state representations: The lateral orbitofrontal cortex (lOFC) receives afferents conveying sensory information from visual, olfactory, gustatory, and somatosensory cortices, spatial and memory information from the hippocampus, and emotional information from the amygdala, the parafascicular nucleus of the thalamus (PF) receives sensory inputs from the gustatory cortex and somatosensory cortex, as well as action planning and execution, arousal/attentional information from the lateral tegmental nucleus, zona incerta, primary reticular nucleus, entopeduncular nucleus, and the primary motor cortex. Each structure performs independent integration of these inputs, and then either communicates directly via PF→lateral OFC→striatal cholinergic interneurons (CINs), or by converging lateral OFC→striatal CINs/PF→striatal CINs projections to form a cohesive, single internal state representation. Striatal CINs then modulate the striatal projection neurons (SPNs) to influence action selection according to the internal state.