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. 2021 Mar 25;11:618662. doi: 10.3389/fonc.2021.618662

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Copyright © 2021 Luo, Zhou, Jiang, Wang, Ji and Shang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-19a-3p targets 3’UTR of PTEN. (A) Putative miRNAs that target the PTEN. The bioinformatics analysis was applied based on miRDB, miRtarbase, RegRNA2.0 and TargetScan. (B) The expression of predicted miRNA in sEVs derived from K7M2 cells determined by qRT-PCR. (C) qRT-PCR analysis of the effect of sEVs on miR-19a-3p expression after 4 days induction of RAW264.7 cells. (D) The miR-19a-3p binding site in PTEN 3’UTR. (E, F) Analysis of luciferase activity. 293E cells were co-transfected with the miR-19a-3p oligos and the wild-type or mutated type 3’UTR of PTEN, and luciferase activity was detected after 48 hours. Values are mean ± SEM of three independent experiments. **P < 0.01.