Table 1.
Patient characteristics at baseline, overall and in patients with or without hypertension before the onset of non‐valvular atrial fibrillation
| Overall (n = 7885) | Pre‐existing hypertension | |||
|---|---|---|---|---|
| No (n = 3884) | Yes (n = 4001) | P‐value | ||
| Age, years | 53.8 ± 10.0 | 50.9 ± 10.4 | 56.6 ± 8.7 | <.001 |
| Age ≥75 y, n (%) | 20 (0.3) | 2 (0.1) | 18 (0.5) | <.001 |
| Female, n (%) | 1491 (18.9) | 874 (22.5) | 617 (15.4) | <.001 |
| SBP, mm Hg | 126.4 ± 17.2 | 120.8 ± 14.8 | 131.7 ± 17.7 | <.001 |
| DBP, mm Hg | 78.5 ± 12.1 | 75.1 ± 10.8 | 81.9 ± 12.3 | <.001 |
| Comorbidities, n (%) | ||||
| Diabetes mellitus | 4364 (55.4) | 1646 (42.4) | 2718 (67.9) | <.001 |
| Dyslipidemia | 3587 (45.5) | 1223 (31.5) | 2364 (59.1) | <.001 |
| Chronic kidney disease | 182 (2.3) | 24 (0.6) | 158 (4.0) | <.001 |
| COPD | 125 (1.6) | 48 (1.2) | 77 (1.9) | .014 |
| Hyperthyroidism | 2041 (25.9) | 1012 (26.1) | 1029 (25.7) | .733 |
| Hypothyroidism | 809 (10.3) | 354 (9.1) | 455 (11.4) | <.001 |
| Coronary heart disease | 3484 (44.2) | 1405 (36.2) | 2079 (52.0) | <.001 |
| Cardiomyopathy | 335 (4.3) | 98 (2.5) | 237 (5.9) | <.001 |
| Congestive heart failure | 3759 (47.7) | 1484 (38.2) | 2275 (56.9) | <.001 |
| Stroke/TIA | 1367 (17.3) | 479 (12.3) | 888 (22.2) | <.001 |
| CHADS2 score at NVAF diagnosis, n (%) | ||||
| 0 | 1481 (18.8) | 1481 (38.1) | 0 | <.001 |
| 1 | 1811 (23.0) | 1144 (29.5) | 667 (16.7) | |
| 2 | 2027 (25.7) | 949 (24.4) | 1078 (26.9) | |
| 3 | 1682 (21.3) | 192 (4.9) | 1490 (37.2) | |
| 4 | 455 (5.8) | 118 (3.0) | 337 (8.4) | |
| 5 | 427 (5.4) | 0 | 427 (10.7) | |
| 6 | 2 (0.1) | 0 | 2 (0.1) | |
Values are mean ± standard deviation, or number of patients (%).
Abbreviations: COPD, chronic obstructive pulmonary disease; DBP, diastolic blood pressure; SBP, systolic blood pressure; TIA, transient ischemic attack.