Table 1. Fifteen SNPs associated with fasting plasma glucose (FPG) and used to construct the FPG genetic score.
| Chr:Pos (hg19) | SNP
(proxy) a |
Locus | Effect/Other
Alleles (Proxy) |
Effect Allele
Frequency (Proxy) b |
Beta
(mmol/L) c |
|---|---|---|---|---|---|
| 1:214159256 | rs340874 | PROX1 | C/T | 0.57 | 0.013 |
| 2:27741237 | rs780094 | GCKR | C/T | 0.62 | 0.029 |
| 2:169763148 | rs560887 | G6PC2 | C/T | 0.70 | 0.075 |
| 3:123065778 | rs11708067
(rs2877716) |
ADCY5 | A/G
(C/T) |
0.75
(0.73) |
0.027 |
| 3:170717521 | rs11920090 | SLC2A2 | T/A | 0.88 | 0.020 |
| 7:15064309 | rs2191349 |
DGKB/
TMEM195 |
T/G | 0.55 | 0.030 |
| 7:44235668 | rs4607517
(rs1799884) |
GCK | A/G
(T/C) |
0.18
(0.18) |
0.062 |
| 8:118184783 | rs13266634 | SLC30A8 | C/T | 0.69 | 0.027 |
| 9:4289050 | rs7034200 | GLIS3 | A/C | 0.48 | 0.018 |
| 10:114758349 | rs7903146 | TCF7L2 | T/C | 0.29 | 0.023 |
| 11:45873091 | rs11605924 | CRY2 | A/C | 0.48 | 0.015 |
| 11:47336320 | rs7944584 | MADD | A/T | 0.72 | 0.021 |
| 11:61571478 | rs174550 | FADS1 | T/C | 0.65 | 0.017 |
| 11:92708710 | rs10830963 | MTNR1B | G/C | 0.28 | 0.067 |
| 15:62433962 | rs11071657 | C2CD4B | A/G | 0.62 | 0.008 |
SNP, single nucleotide polymorphism. aProxy SNPs were genotyped and analysed in the Hyperglycemia and Adverse Pregnancy Outcome Study (both r 2 > 0.85 in 340,000 British white unrelated samples from Version 3 release of UK Biobank 24, calculated using PLINK software 25). bEffect allele frequency was calculated in 340,000 British white unrelated samples from the UK Biobank 24. cBeta values were aligned to the trait-raising allele on the + strand (Human Genome Assembly Reference hg19). Source of SNPs and beta values: Dupuis et al., 2010 9. We used the same Beta values for proxy SNPs. We excluded rs10885122 ( ADRA2A locus) due to deviation from Hardy-Weinberg Equilibrium in the Atlantic Diabetes In Pregnancy Study (Bonferroni corrected P < 0.05).