Table 4. Associations for fasting plasma glucose (FPG) and type 2 diabetes (T2D) genetic scores (GS) with different measures of glucose tolerance in women with and without diabetes in the Hyperglycemia and Adverse Pregnancy Outcome Study (A) ^a and the Atlantic Diabetes in Pregnancy Study (B) ^b.

(A) HAPO
Glucose measure	Beta coefficient (mmol/L) per one unit higher FPG GS (95%CI)	Beta coefficient (mmol/L) per one unit higher FPG GS, with adjustment for other glucose values (95% CI)	Beta coefficient (mmol/L) per one unit higher T2D GS (95% CI)	Beta coefficient (mmol/L) per one unit higher T2D GS, with adjustment for other glucose values (95% CI)
Fasting	0.028 (0.023-0.032) ***	0.022 (0.018-0.027) ***	0.008 (0.004-0.011) ***	0.003 (-3.8 x 10 -4-0.006 )
1-hr c	0.060 (0.040-0.081) ***	0.009 (-0.007-0.025)	0.051 (0.037-0.066) ***	0.019 (0.008-0.031) **
2-hr c	0.032 (0.016-0.048) ***	0.0003 (-0.013-0.013 )	0.034 (0.022-0.045) ***	0.009 (0.00001-0.018)
(B) DIP
Glucose measure	Beta coefficient (mmol/L) per one unit higher FPG GS (95%CI)	Beta coefficient (mmol/L) per one unit higher FPG GS, with adjustment for other glucose values (95% CI)	Beta coefficient (mmol/L) per one unit higher T2D GS (95% CI)	Beta coefficient (mmol/L) per one unit higher T2D GS, with adjustment for other glucose values (95% CI)
Fasting	0.050 (0.039-0.061) ***	0.030 (0.021-0.039) ***	0.016 (0.008-0.025) **	-0.001 (-0.008-0.006)
1-hr c	0.136 (0.093-0.179) ***	0.034 (-9.35 x 10 -6-0.067 )	0.110 (0.079-0.141 mmol/L) ***	0.055 (0.030-0.078) ***
2-hr c	0.071 (0.038-0.105) ***	-0.015 (-0.042-0.011 )	0.065 (0.041-0.089) ***	0.014 (-0.005-0.033)

CI, confidence interval; DIP, Atlantic Diabetes in Pregnancy Study; HAPO, Hyperglycemia and Adverse Pregnancy Outcome Study. ^aThese analyses were performed in HAPO as it was a representative sample of pregnant women of European ancestry. ^bAs ATLANTIC-DIP had a case-control design the beta coefficients will not be representative of the general pregnant population but are presented for comparison with HAPO. ^cThe 1-hour and 2-hour glucose measures refer to the glucose level measured at 1 and 2 hours, respectively, following a 75 g oral glucose load as part of an oral glucose tolerance test. ^** P value <0.001, <0.01 after Bonferroni correction. ^*** P value <0.001, remained <0.001 after Bonferroni correction.