Table 2.
Cohort analysis of one year follow-up of girls aged 11-14 years vaccinated in South Korea in 2017
| Organ system disorders | HPV vaccinated group | HPV unvaccinated group | |||||
|---|---|---|---|---|---|---|---|
| No of serious adverse events | Person years | Incidence rate* (95% CI) | No of serious adverse events | Person years | Incidence rate* (95% CI) | ||
| Endocrine diseases: | |||||||
| Graves’ disease | 136 | 408 038 | 33.3 (28.2 to 39.4) | 20 | 60 579 | 33.0 (21.3 to 51.2) | |
| Hashimoto’s thyroiditis | 215 | 407 768 | 52.7 (46.1 to 60.3) | 22 | 60 547 | 36.3 (23.9 to 55.2) | |
| Hyperthyroidism | 508 | 407 603 | 124.6 (114.3 to 136.0) | 61 | 60 533 | 100.8 (78.4 to 129.5) | |
| Hypothyroidism | 1227 | 406 033 | 302.2 (285.7 to 319.6) | 138 | 60 350 | 228.7 (193.5 to 270.2) | |
| Type 1 diabetes | 82 | 408 331 | 20.1 (16.2 to 24.9) | 17 | 60 623 | 28.0 (17.4 to 45.1) | |
| Gastrointestinal diseases: | |||||||
| Crohn’s disease | 83 | 408 239 | 20.3 (16.4 to 25.2) | 7 | 60 615 | 11.6 (5.5 to 24.2) | |
| Ulcerative colitis | 25 | 408 310 | 6.1 (4.1 to 9.1) | 4 | 60 627 | 6.6 (2.5 to 17.6) | |
| Peptic ulcer diseases | 6297 | 397 433 | 1584.0 (1546.0 to 1624.0) | 770 | 59 422 | 1296.0 (1207.0 to 1391.0) | |
| Pancreatitis | 902 | 406 716 | 221.8 (207.8 to 236.7) | 114 | 60 400 | 188.7 (157.1 to 226.8) | |
| Cardiovascular diseases: | |||||||
| Raynaud’s disease | 39 | 408 327 | 9.6 (7.0 to 13.1) | 3 | 60 628 | 5.0 (1.6 to 15.3) | |
| Venous thromboembolism | 26 | 408 340 | 6.4 (4.3 to 9.4) | 6 | 60 628 | 9.9 (4.5 to 22.0) | |
| Vasculitis | 161 | 408 129 | 39.5 (33.8 to 46.0) | 27 | 60 605 | 44.6 (30.6 to 65.0) | |
| Hypotension | 792 | 407 401 | 194.4 (181.3 to 208.4) | 87 | 60 543 | 143.7 (116.5 to 177.3) | |
| Musculoskeletal and systemic diseases: | |||||||
| Ankylosing spondylitis | 8 | 408 361 | 2.0 (1.0 to 3.9) | 0 | 60 632 | 0.0 (0.0 to 0.0) | |
| Behcet’s syndrome | 27 | 408 322 | 6.6 (4.5 to 9.6) | 5 | 60 627 | 8.3 (3.4 to 19.8) | |
| Juvenile arthritis | 78 | 408 181 | 19.1 (15.3 to 23.9) | 11 | 60 601 | 18.2 (10.1 to 32.8) | |
| Rheumatoid arthritis | 685 | 407 378 | 168.1 (156.0 to 181.2) | 88 | 60 515 | 145.4 (118.0 to 179.2) | |
| Systemic lupus erythematosus | 15 | 408 340 | 3.7 (2.2 to 6.1) | 0 | 60 626 | 0.0 (0.0 to 0.0) | |
| Haematological diseases: | |||||||
| Idiopathic thrombocytopenic purpura | 28 | 408 292 | 6.9 (4.7 to 9.9) | 9 | 60 615 | 14.9 (7.7 to 28.5) | |
| Henoch-Schönlein’s purpura | 246 | 407 892 | 60.3 (53.2 to 68.3) | 50 | 60 534 | 82.6 (62.6 to 109.0) | |
| Dermatological diseases: | |||||||
| Erythema nodosum | 26 | 408 332 | 6.4 (4.3 to 9.4) | 0 | 60 628 | 0.0 (0.0 to 0.0) | |
| Psoriasis | 624 | 407 071 | 153.3 (141.7 to 165.8) | 94 | 60 469 | 155.5 (127.0 to 190.3) | |
| Neurological diseases: | |||||||
| Bell’s palsy | 102 | 408 196 | 25.0 (20.6 to 30.3) | 17 | 60 607 | 28.1 (17.4 to 45.1) | |
| Epilepsy | 595 | 406 345 | 146.4 (135.1 to 158.7) | 74 | 60 325 | 122.7 (97.7 to 154.1) | |
| Narcolepsy | 33 | 408 335 | 8.1 (5.8 to 11.4) | 4 | 60 628 | 6.6 (2.5 to 17.6) | |
| Paralysis | 19 | 408 345 | 4.7 (3.0 to 7.3) | 4 | 60 626 | 6.6 (2.5 to 17.6) | |
| Migraine | 4949 | 400 699 | 1235.0 (1201.0 to 1270.0) | 551 | 59 835 | 920.9 (847.1 to 1001.0) | |
| Guillain-Barré syndrome | 5 | 408 363 | 1.2 (0.5 to 2.9) | 5 | 60 626 | 8.3 (3.4 to 19.8) | |
| Optical neuritis | 103 | 408 211 | 25.2 (20.8 to 30.6) | 9 | 60 612 | 14.9 (7.7 to 28.5) | |
| Neuralgia and neuritis | 431 | 407 703 | 105.7 (96.2 to 116.2) | 62 | 60 555 | 102.4 (79.8 to 131.3) | |
| Intracerebral haemorrhage | 38 | 408 306 | 9.3 (6.8 to 12.8) | 3 | 60 622 | 5.0 (1.6 to 15.3) | |
| Extrapyramidal and movement disorders | 215 | 408 106 | 52.7 (46.1 to 60.2) | 29 | 60 594 | 47.9 (33.3 to 68.9) | |
| Tuberculosis | 110 | 408 143 | 27.0 (22.4 to 32.5) | 14 | 60 612 | 23.1 (13.7 to 39.0) | |
HPV=human papillomavirus.
*
Events per 100 000 person years.