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. Author manuscript; available in PMC: 2021 Apr 8.
Published in final edited form as: Cell Rep. 2020 Sep 8;32(10):108125. doi: 10.1016/j.celrep.2020.108125

Figure 1. Atf-6 Is Dispensable in Proteotoxic Stress, and Mutants Exhibit Extended Lifespans.

Figure 1.

(A) Survival analysis of UPR mutant nematodes exposed chronically to 30 mg/mL tunicamycin starting on the first day of adulthood (n = 72 per condition).

(B) Lifespan analysis of atf-6 mutants (n = 100 per condition).

(C) Pharyngeal pumping rates as a measure of health span in 7-day old nematodes (means ± SDs of n = 31 combined over 2 independent repeats).

(D) Period of the defecation motor program, an ultradian behavioral rhythm, in aging nematodes (means ± SDs of n = 20–40 total periods measured from 4–5 animals on each day).

(E) Survival of worms exposed to high temperatures for 3 and 4 h (means ± SDs of 3 independent assays of 100 animals).

(F) Fecundity in atf-6 mutants over the first 3 days of adulthood (means ± SDs of n = 5–19 worms per day).