Table 2.
Diuretics | Beta blockers | RAS blockers | CCB | |
---|---|---|---|---|
N | 13 808 | 20 538 | 35 783 | 9159 |
Three‐y outcomes (30 until 1095 d after index); before propensity matching | ||||
First stroke (I63) (%) | 0.7 | 1.3 | 0.8 | 1.3 |
Any cerebrovascular outcome (I60‐I69) (%) | 2.5 | 3.9 | 2.4 | 4.1 |
Myocardial infarction (I21) (%) | 0.2 | 0.9 | 0.2 | 0.3 |
Any ischemic heart disease (I20‐I25) (%) | 2.8 | 6.6 | 2.6 | 4.1 |
Chronic kidney disease (N18, I12, I13) (%) | 2.3 | 2.4 | 2.6 | 3.0 |
Any of these CV outcomes (%) | 5.2 | 9.5 | 5.4 | 7.6 |
Efficacy parameters | ||||
LDL cholesterol, mg/dL | 114.7 | 108.1 | 109.24 | 110.32 |
−2.9 | −4.4 | −6.1 | −3.3 | |
Uncontrolled BP values, any episode (%) | 42.9 | 45.9 | 28.7 | 35.8 |
Man systolic BP, most recent value, mm Hg | 128.7 | 128.1 | 128.9 | 132.2 |
±SD | 15.4 | 16.7 | 15.1 | 16.2 |
Difference to baseline | −4.9 | −3.6 | −5.8 | −4.8 |
Mean diastolic BP, most recent value, mm Hg | 77.1 | 76.0 | 77.2 | 77.7 |
±SD | 10.5 | 10.6 | 10.0 | 10.5 |
Difference to baseline | −3.1 | −2.2 | −3.8 | −3.2 |
Heart rate/min | 78.1 | 72.7 | 77.3 | 77.1 |
Difference to baseline | −2.2 | −4.9 | −1.5 | −2.1 |
Mean C‐reactive protein, most recent value, mg/L, mean |
8.3 | 8.5 | 9.3 | 6.8 |
Difference to baseline | −1.2 | 0.8 | 0.4 | −0.1 |