Table 3.
Baseline characteristics and outcome results after pairwise propensity matching (diuretics vs beta blockers and RAS blockers vs CCB)
| Baseline characteristics after propensity matching | Diuretics | Beta blockers | RAS blockers | CCB |
|---|---|---|---|---|
| Number of patients | 11 766 | 11 766 | 8887 | 8887 |
| Number of patients excluded due to propensity matching | 2042 | 8772 | 26896 | 272 |
| In percent (%) | 15 | 43 | 75 | 3 |
| Mean age at start of therapy | 54.9 | 54.8 | 51.6 | 57.8 |
| SD | 14.8 | 15.9 | 16.1 | 15.9 |
| Female (%) | 70.4 | 70.8 | 58.1 | 58.2 |
| White (%) | 77.5 | 77.5 | 62.2 | 62.3 |
| Black (%) | 12.6 | 12.7 | 23.0 | 22.9 |
| Pre−existing conditions | ||||
| Ischemic heart disease (I20‐I25) (%) | 1.9 | 1.9 | 2.6 | 2.5 |
| Diabetes (E08‐E13) (%) | 4.5 | 4.8 | 4.4 | 4.4 |
| Atrial fibrillation (I48) (%) | 1.0 | 0.9 | 1.1 | 1.2 |
| Three‐y outcomes of the matched cohorts | ||||
| First stroke (I63) (%) | 0.7 | 1.1 | 0.7 | 1.3 |
| Any cerebrovascular outcome (I60‐I69) (%) | 2.7 | 3.6 | 2.4 | 4.1 |
| Myocardial infarction (I21) (%) | 0.2 | 0.7 | 0.1 | 0.3 |
| Any ischemic heart disease (I20‐I25) (%) | 2.8 | 6.0 | 2.3 | 3.9 |
| Chronic kidney disease (N18, I12, I13) (%) | 2.5 | 2.4 | 2.6 | 2.9 |
| Any of these CV outcomes (%) | 5.4 | 9.0 | 5.3 | 7.6 |